Vaccine potential of recombinant cathepsin B against Fasciola gigantica

• Main Authors: Pathanin Chantree, Manussabhorn Phatsara, Krai Meemon, Pannigan Chaichanasak, Narin Changklungmoa, Pornanan Kueakhai, Natcha Lorsuwannarat, Kant Sangpairoj, Sineenart Songkoomkrong, Chaitip Wanichanon, Tadashi Itagaki, Prasert Sobhon
• Format: Journal
• Published: 2018
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880422630&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/47685
• Institution: Chiang Mai University

In Fasciola gigantica, cathepsin Bs, especially cathepsin B2 and B3 are expressed in early juvenile stages, and are proposed to mediate the invasion of host tissues. Thus they are thought to be the target vaccine candidates that can block the invasion and migration of the juvenile parasite. To evalu...