Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol

Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectro...

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Main Authors: P. Riangjanapatee, R. H. Müller, C. M. Keck, S. Okonogi
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-476872018-04-25T08:42:49Z Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature. 2018-04-25T08:42:49Z 2018-04-25T08:42:49Z 2013-09-01 Journal 00317144 2-s2.0-84884767399 10.1691/ph.2013.2139 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature.
format Journal
author P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
spellingShingle P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
author_facet P. Riangjanapatee
R. H. Müller
C. M. Keck
S. Okonogi
author_sort P. Riangjanapatee
title Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_short Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_full Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_fullStr Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_full_unstemmed Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
title_sort development of lycopene-loaded nanostructured lipid carriers: effect of rice oil and cholesterol
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687
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