Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol
Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectro...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-47687 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-476872018-04-25T08:42:49Z Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature. 2018-04-25T08:42:49Z 2018-04-25T08:42:49Z 2013-09-01 Journal 00317144 2-s2.0-84884767399 10.1691/ph.2013.2139 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
description |
Nanostructured lipid carriers (NLC) were developed using a skin-compatible surfactant and natural lipid materials (rice oil, cholesterol) to incorporate lycopene. Characteristics of the NLC were explored in comparison with nanoemulsions and solid-lipid nanoparticles (SLN). Photon correlation spectroscopy, laser diffractometry (LD) and differential scanning calorimetry were used to determine particle size and thermal stability. Particle size expressed as LD (0.99) was 405nm for the SLN, 350nm for the NLC without cholesterol and 287nm for the NLC with cholesterol. Rice oil and cholesterol enabled the formation of smaller particles, but cholesterol also reduced drug stability in the NLC. To preserve chemical stability of lycopene in the NLC, cholesterol should be avoided and storage should be at 4 °C or at room temperature. |
format |
Journal |
author |
P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi |
spellingShingle |
P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
author_facet |
P. Riangjanapatee R. H. Müller C. M. Keck S. Okonogi |
author_sort |
P. Riangjanapatee |
title |
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
title_short |
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
title_full |
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
title_fullStr |
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
title_full_unstemmed |
Development of lycopene-loaded nanostructured lipid carriers: Effect of rice oil and cholesterol |
title_sort |
development of lycopene-loaded nanostructured lipid carriers: effect of rice oil and cholesterol |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84884767399&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47687 |
_version_ |
1681423108247912448 |