Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino
Ethnopharmacological relevance To evaluate the safety of standardized extract of Gynostemma pentaphyllum in rats. Materials and methods The water extract of Gynostemma pentaphyllum was prepared and standardized, the dry powder yielded 6% gypenosides. In the acute oral toxicity test, the single oral...
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th-cmuir.6653943832-477032018-04-25T08:43:01Z Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino Natthakarn Chiranthanut Supanimit Teekachunhatean Ampai Panthong Parirat Khonsung Duangta Kanjanapothi Nirush Lertprasertsuk Ethnopharmacological relevance To evaluate the safety of standardized extract of Gynostemma pentaphyllum in rats. Materials and methods The water extract of Gynostemma pentaphyllum was prepared and standardized, the dry powder yielded 6% gypenosides. In the acute oral toxicity test, the single oral dose of 5000 mg/kg of Gynostemma pentaphyllum extract was given to female Sprague-Dawley rats. In subchronic toxicity test, the oral dose of 1000 mg/kg/day of the extract was given to rats in treatment and satellite groups for 90 days. Satellite groups of both sexes were kept for additional 28 days after 90-day treatment. Control rats received distilled water. Results Standardized extract of Gynostemma pentaphyllum did not cause death or any toxic signs in rats. The daily administration of the extract for 90 days did not produce lethal or harmful effects. Although certain hematological and blood chemistry values (i.e.; neutrophil, monocyte, glucose, and serum alkaline phosphatase levels) were found to be statistically different from the control group, however; these values were within the ranges of normal rats. Conclusion Standardized extract of Gynostemma pentaphyllum did not produce mortality or any abnormality in rats. © 2013 Elsevier B.V. 2018-04-25T08:43:01Z 2018-04-25T08:43:01Z 2013-08-26 Journal 18727573 03788741 2-s2.0-84882268698 10.1016/j.jep.2013.06.027 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882268698&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47703 |
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Ethnopharmacological relevance To evaluate the safety of standardized extract of Gynostemma pentaphyllum in rats. Materials and methods The water extract of Gynostemma pentaphyllum was prepared and standardized, the dry powder yielded 6% gypenosides. In the acute oral toxicity test, the single oral dose of 5000 mg/kg of Gynostemma pentaphyllum extract was given to female Sprague-Dawley rats. In subchronic toxicity test, the oral dose of 1000 mg/kg/day of the extract was given to rats in treatment and satellite groups for 90 days. Satellite groups of both sexes were kept for additional 28 days after 90-day treatment. Control rats received distilled water. Results Standardized extract of Gynostemma pentaphyllum did not cause death or any toxic signs in rats. The daily administration of the extract for 90 days did not produce lethal or harmful effects. Although certain hematological and blood chemistry values (i.e.; neutrophil, monocyte, glucose, and serum alkaline phosphatase levels) were found to be statistically different from the control group, however; these values were within the ranges of normal rats. Conclusion Standardized extract of Gynostemma pentaphyllum did not produce mortality or any abnormality in rats. © 2013 Elsevier B.V. |
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Natthakarn Chiranthanut Supanimit Teekachunhatean Ampai Panthong Parirat Khonsung Duangta Kanjanapothi Nirush Lertprasertsuk |
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Natthakarn Chiranthanut Supanimit Teekachunhatean Ampai Panthong Parirat Khonsung Duangta Kanjanapothi Nirush Lertprasertsuk Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
author_facet |
Natthakarn Chiranthanut Supanimit Teekachunhatean Ampai Panthong Parirat Khonsung Duangta Kanjanapothi Nirush Lertprasertsuk |
author_sort |
Natthakarn Chiranthanut |
title |
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
title_short |
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
title_full |
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
title_fullStr |
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
title_full_unstemmed |
Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino |
title_sort |
toxicity evaluation of standardized extract of gynostemma pentaphyllum makino |
publishDate |
2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84882268698&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47703 |
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1681423111331774464 |