Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy

Objectives-The purpose of this study was to evaluate the efficacy of the fetal cardiac circumference derived by spatiotemporal image correlation (STIC) for predicting fetal hemoglobin (Hb) Bart disease. Methods-Pregnancies at risk of fetal Hb Bart disease at 17 to 22 weeks' gestation were enrol...

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Main Authors: Woralak Siwawong, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Theera Tongsong
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880853872&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47753
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-477532018-04-25T08:43:36Z Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy Woralak Siwawong Fuanglada Tongprasert Kasemsri Srisupundit Suchaya Luewan Theera Tongsong Objectives-The purpose of this study was to evaluate the efficacy of the fetal cardiac circumference derived by spatiotemporal image correlation (STIC) for predicting fetal hemoglobin (Hb) Bart disease. Methods-Pregnancies at risk of fetal Hb Bart disease at 17 to 22 weeks' gestation were enrolled. All underwent STIC volume acquisition for analysis of fetal cardiac dimensions and cordocentesis for Hb level and Hb typing analysis. Spatiotemporal image correlation volume data sets were subsequently analyzed offline for cardiac circumference measurements, which were used to evaluate the efficacy in predicting fetal anemia and fetal Hb Bart disease. Results-A total of 88 pregnancies at risk of fetal Hb Bart disease at 17 to 22 weeks were recruited into the study. The cardiac circumference was significantly higher in fetuses with Hb Bart disease than in unaffected fetuses (1.33 and 1.02 multiples of the median [MoM], respectively; P < .001). The cardiac circumference effectively predicted fetal Hb Bart disease (area under the receiver operating characteristic curve, 0.85; 95% confidence interval [CI], 0.73-0.97), with sensitivity of 86.4% (95% CI, 72.0%-100%) and specificity of 78.1% (95% CI, 68.0%-88.3%) using a cutoff point of greater than 1.17 MoM, whereas the cardiothoracic ratio had better efficacy, with sensitivity of 90.9% (95% CI, 78.9%-100%) and specificity of 85.9% (95% CI, 77.4%-94.5%) using a cutoff point of greater than 0.50. Conclusions-At midpregnancy, a cardiac circumference of greater than 1.17 MoM can be used as an alternative sonographic marker for predicting fetal Hb Bart disease, although not perfectly. However, the cardiothoracic ratio seems to be more accurate than the cardiac circumference for such a purpose. © 2013 by the American Institute of Ultrasound in Medicine. 2018-04-25T08:43:36Z 2018-04-25T08:43:36Z 2013-08-01 Journal 15509613 02784297 2-s2.0-84880853872 10.7863/ultra.32.8.1483 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880853872&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47753
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objectives-The purpose of this study was to evaluate the efficacy of the fetal cardiac circumference derived by spatiotemporal image correlation (STIC) for predicting fetal hemoglobin (Hb) Bart disease. Methods-Pregnancies at risk of fetal Hb Bart disease at 17 to 22 weeks' gestation were enrolled. All underwent STIC volume acquisition for analysis of fetal cardiac dimensions and cordocentesis for Hb level and Hb typing analysis. Spatiotemporal image correlation volume data sets were subsequently analyzed offline for cardiac circumference measurements, which were used to evaluate the efficacy in predicting fetal anemia and fetal Hb Bart disease. Results-A total of 88 pregnancies at risk of fetal Hb Bart disease at 17 to 22 weeks were recruited into the study. The cardiac circumference was significantly higher in fetuses with Hb Bart disease than in unaffected fetuses (1.33 and 1.02 multiples of the median [MoM], respectively; P < .001). The cardiac circumference effectively predicted fetal Hb Bart disease (area under the receiver operating characteristic curve, 0.85; 95% confidence interval [CI], 0.73-0.97), with sensitivity of 86.4% (95% CI, 72.0%-100%) and specificity of 78.1% (95% CI, 68.0%-88.3%) using a cutoff point of greater than 1.17 MoM, whereas the cardiothoracic ratio had better efficacy, with sensitivity of 90.9% (95% CI, 78.9%-100%) and specificity of 85.9% (95% CI, 77.4%-94.5%) using a cutoff point of greater than 0.50. Conclusions-At midpregnancy, a cardiac circumference of greater than 1.17 MoM can be used as an alternative sonographic marker for predicting fetal Hb Bart disease, although not perfectly. However, the cardiothoracic ratio seems to be more accurate than the cardiac circumference for such a purpose. © 2013 by the American Institute of Ultrasound in Medicine.
format Journal
author Woralak Siwawong
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
spellingShingle Woralak Siwawong
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
author_facet Woralak Siwawong
Fuanglada Tongprasert
Kasemsri Srisupundit
Suchaya Luewan
Theera Tongsong
author_sort Woralak Siwawong
title Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
title_short Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
title_full Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
title_fullStr Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
title_full_unstemmed Fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
title_sort fetal cardiac circumference derived by spatiotemporal image correlation as a predictor of fetal hemoglobin bart disease at midpregnancy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880853872&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47753
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