Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin

Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared...

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Main Authors: Manokruang K., Lym J.S., Lee D.S.
Format: Article
Language:English
Published: Elsevier 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395106&partnerID=40&md5=9192ace181452f7ba5bac32ca536f62b
http://cmuir.cmu.ac.th/handle/6653943832/4777
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spelling th-cmuir.6653943832-47772014-08-30T02:55:45Z Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin Manokruang K. Lym J.S. Lee D.S. Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V. 2014-08-30T02:55:45Z 2014-08-30T02:55:45Z 2014 Article 0167577X 10.1016/j.matlet.2014.03.052 MLETD http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395106&partnerID=40&md5=9192ace181452f7ba5bac32ca536f62b http://cmuir.cmu.ac.th/handle/6653943832/4777 English Elsevier
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Poly(amino urethane) (PAU) conjugated bovine serum albumin (BSA) hydrogels were prepared in a sequential step synthesis. The synthesis included preparation of PAUs, acrylation of the synthesized PAUs and conjugation of PAUs to BSA. The conjugation reaction was confirmed by Fourier transform infrared spectrometry (FT-IR) and sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). The conjugate exhibited pH and temperature induced sol-gel phase transitions, facilitating the DOX-loaded conjugate solution to form gels at the physiological conditions. The release of DOX from the conjugate hydrogel proceeded without the initial burst and persisted over 5 weeks. The cytotoxicity results showed that the conjugate was non-cytotoxic, allowing uses of this material in bioapplications. © 2014 Elsevier B.V.
format Article
author Manokruang K.
Lym J.S.
Lee D.S.
spellingShingle Manokruang K.
Lym J.S.
Lee D.S.
Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
author_facet Manokruang K.
Lym J.S.
Lee D.S.
author_sort Manokruang K.
title Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_short Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_full Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_fullStr Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_full_unstemmed Injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
title_sort injectable hydrogels based on poly(amino urethane) conjugated bovine serum albumin
publisher Elsevier
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84897395106&partnerID=40&md5=9192ace181452f7ba5bac32ca536f62b
http://cmuir.cmu.ac.th/handle/6653943832/4777
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