Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand

In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (P...

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Main Authors: Arunrat Tangmunkongvorakul, Suwat Chariyalertsak, K. Rivet Amico, Pongpun Saokhieo, Vorawan Wannalak, Thirayut Sangangamsakun, Pedro Goicochea, Robert Grant
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880513142&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47770
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-477702018-04-25T08:43:46Z Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand Arunrat Tangmunkongvorakul Suwat Chariyalertsak K. Rivet Amico Pongpun Saokhieo Vorawan Wannalak Thirayut Sangangamsakun Pedro Goicochea Robert Grant In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (PrEP) HIV prevention strategy. To better understand the characteristics of iPrEx participants specifically from this underserved population in Thailand, and gain insights into their experiences of trying to take a daily tablet as part of this blinded PrEP trial, we conducted a qualitative study. In 2010, 32 MSM iPrEx participants provided in-depth interviews and an additional 14 joined focus group discussions. Results of the qualitative analyzes suggested that participants held generally positive attitudes toward the iPrEx study and study medication and related this to high rates of adherence to the daily regimen. Participants also reflected on the provision of quality health care as part of participation in the trial, as well as support from clinical research staff, family and friends as helpful in supporting high rates of study medication adherence. Discourse concerning challenges to adherence included medication taking behavior, which was contextualized b y lifestyle, living arrangement, social life, social stigma in terms of being mistakenly identified as HIV positive or unintentional disclosure of sexual identity to family and friends, and relationship conflicts with partners. The results provide broader perspectives of participant experiences of the study medication and daily adherence in the larger contexts of the MSM community, close relationships, and the study climate, and can be leveraged in constructing PrEP adherence support approaches within these communities. © 2013 Taylor & Francis. 2018-04-25T08:43:46Z 2018-04-25T08:43:46Z 2013-08-01 Journal 13600451 09540121 2-s2.0-84880513142 10.1080/09540121.2012.748871 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880513142&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47770
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description In 2008, the Pre-exposure Prophylaxis Initiative (iPrEx) study expanded to include men who have sex with men (MSM) in Chiang Mai, Thailand. In full, 114 participants from Chiang Mai joined this international double-blinded trial of daily FTC-TDF (Truvada®) or placebo as a pre-exposure prophylaxis (PrEP) HIV prevention strategy. To better understand the characteristics of iPrEx participants specifically from this underserved population in Thailand, and gain insights into their experiences of trying to take a daily tablet as part of this blinded PrEP trial, we conducted a qualitative study. In 2010, 32 MSM iPrEx participants provided in-depth interviews and an additional 14 joined focus group discussions. Results of the qualitative analyzes suggested that participants held generally positive attitudes toward the iPrEx study and study medication and related this to high rates of adherence to the daily regimen. Participants also reflected on the provision of quality health care as part of participation in the trial, as well as support from clinical research staff, family and friends as helpful in supporting high rates of study medication adherence. Discourse concerning challenges to adherence included medication taking behavior, which was contextualized b y lifestyle, living arrangement, social life, social stigma in terms of being mistakenly identified as HIV positive or unintentional disclosure of sexual identity to family and friends, and relationship conflicts with partners. The results provide broader perspectives of participant experiences of the study medication and daily adherence in the larger contexts of the MSM community, close relationships, and the study climate, and can be leveraged in constructing PrEP adherence support approaches within these communities. © 2013 Taylor & Francis.
format Journal
author Arunrat Tangmunkongvorakul
Suwat Chariyalertsak
K. Rivet Amico
Pongpun Saokhieo
Vorawan Wannalak
Thirayut Sangangamsakun
Pedro Goicochea
Robert Grant
spellingShingle Arunrat Tangmunkongvorakul
Suwat Chariyalertsak
K. Rivet Amico
Pongpun Saokhieo
Vorawan Wannalak
Thirayut Sangangamsakun
Pedro Goicochea
Robert Grant
Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
author_facet Arunrat Tangmunkongvorakul
Suwat Chariyalertsak
K. Rivet Amico
Pongpun Saokhieo
Vorawan Wannalak
Thirayut Sangangamsakun
Pedro Goicochea
Robert Grant
author_sort Arunrat Tangmunkongvorakul
title Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_short Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_full Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_fullStr Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_full_unstemmed Facilitators and barriers to medication adherence in an HIV prevention study among men who have sex with men in the iPrEx study in Chiang Mai, Thailand
title_sort facilitators and barriers to medication adherence in an hiv prevention study among men who have sex with men in the iprex study in chiang mai, thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880513142&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47770
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