Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions

It has been well established that the bone marrow (BM) is a radiosensitive tissue, but the radiosensitivity of the heart is poorly understood. In this study, we investigated the comparative effects of 28 Silicon ( 28 Si) ions (one type of heavy ion found in space) on tissue from the heart and the BM...

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Main Authors: Montree Tungjai, Elbert B. Whorton, Kanokporn Noy Rithidech
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880919665&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47773
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spelling th-cmuir.6653943832-477732018-04-25T08:43:53Z Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions Montree Tungjai Elbert B. Whorton Kanokporn Noy Rithidech It has been well established that the bone marrow (BM) is a radiosensitive tissue, but the radiosensitivity of the heart is poorly understood. In this study, we investigated the comparative effects of 28 Silicon ( 28 Si) ions (one type of heavy ion found in space) on tissue from the heart and the BM of exposed mice. We gave adult male CBA/CaJ mice a whole-body exposure to a total dose of 0, 0.1, 0.25, or 0.5 Gy of 300 MeV/nucleon (n) 28 Si ions, using a fractionated schedule (two exposures, 15 days apart that totaled each selected dose). The heart and BM were collected from 5 mice per treatment group at various times up to 6 months post-irradiation. In each mouse, we obtained tissue lysates from the heart and from the total population of BM cells for measuring the levels of cleaved poly (ADP-ribose) polymerase (cleaved PARP, a marker of apoptotic cell death) and the levels of activated nuclear factor-kappa B (NF-κB) and selected NF-κB- regulated cytokines known to be involved in inflammatory responses. Our data showed that, up to 6 months post-irradiation, the levels of apoptotic cell death and inflammatory responses in tissues from the heart and BM collected from exposed mice were statistically higher than those in sham controls. Hence, these findings are suggestive of chronic apoptotic cell death and inflammation in both tissues after exposure to 28 Si ions. In summary, our data are indicative of a possible association between exposure to 28 Si ions during space flight and long-term health risk. © 2013 Springer-Verlag Berlin Heidelberg. 2018-04-25T08:43:53Z 2018-04-25T08:43:53Z 2013-08-01 Journal 0301634X 2-s2.0-84880919665 10.1007/s00411-013-0479-4 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880919665&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/47773
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
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description It has been well established that the bone marrow (BM) is a radiosensitive tissue, but the radiosensitivity of the heart is poorly understood. In this study, we investigated the comparative effects of 28 Silicon ( 28 Si) ions (one type of heavy ion found in space) on tissue from the heart and the BM of exposed mice. We gave adult male CBA/CaJ mice a whole-body exposure to a total dose of 0, 0.1, 0.25, or 0.5 Gy of 300 MeV/nucleon (n) 28 Si ions, using a fractionated schedule (two exposures, 15 days apart that totaled each selected dose). The heart and BM were collected from 5 mice per treatment group at various times up to 6 months post-irradiation. In each mouse, we obtained tissue lysates from the heart and from the total population of BM cells for measuring the levels of cleaved poly (ADP-ribose) polymerase (cleaved PARP, a marker of apoptotic cell death) and the levels of activated nuclear factor-kappa B (NF-κB) and selected NF-κB- regulated cytokines known to be involved in inflammatory responses. Our data showed that, up to 6 months post-irradiation, the levels of apoptotic cell death and inflammatory responses in tissues from the heart and BM collected from exposed mice were statistically higher than those in sham controls. Hence, these findings are suggestive of chronic apoptotic cell death and inflammation in both tissues after exposure to 28 Si ions. In summary, our data are indicative of a possible association between exposure to 28 Si ions during space flight and long-term health risk. © 2013 Springer-Verlag Berlin Heidelberg.
format Journal
author Montree Tungjai
Elbert B. Whorton
Kanokporn Noy Rithidech
spellingShingle Montree Tungjai
Elbert B. Whorton
Kanokporn Noy Rithidech
Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
author_facet Montree Tungjai
Elbert B. Whorton
Kanokporn Noy Rithidech
author_sort Montree Tungjai
title Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
title_short Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
title_full Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
title_fullStr Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
title_full_unstemmed Persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>Silicon (<sup>28</sup>Si) ions
title_sort persistence of apoptosis and inflammatory responses in the heart and bone marrow of mice following whole-body exposure to<sup>28</sup>silicon (<sup>28</sup>si) ions
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84880919665&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/47773
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