Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells

The critical step in colorectal cancer progression and associated mortality is cancer invasion, which depends on two key gelatinase enzymes, matrix metalloproteinases-2 and -9. Dried longan (Euphoria longana Lam.) seed is a rich natural source of antioxidant polyphenols.This study evaluated the effe...

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Main Authors: Atita Panyathep, Teera Chewonarin, Khanittha Taneyhill, Usanee Vinitketkumnuen, Young Joon Surh
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876491871&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48006
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spelling th-cmuir.6653943832-480062018-04-25T08:46:34Z Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells Atita Panyathep Teera Chewonarin Khanittha Taneyhill Usanee Vinitketkumnuen Young Joon Surh The critical step in colorectal cancer progression and associated mortality is cancer invasion, which depends on two key gelatinase enzymes, matrix metalloproteinases-2 and -9. Dried longan (Euphoria longana Lam.) seed is a rich natural source of antioxidant polyphenols.This study evaluated the effect of dried longan seeds on colon cancer cell invasion via gelatinase function and expression. Three dried longan seed fractions were collected by Sephadex LH-20 column chromatography. They showed a potent inhibitor on colorectal cancer cell invasion and gelatinase activity. The antigelatinase activities of fractions 1 and 2 were a direct effect via Zn 2+ chelation, whereas fraction 3 modulated indirectly through suppression of zymogen activators. Among the fractions, only fraction 3 reduced the gelatinase expression, which was correlated with the levels of tissue inhibitor of metalloproteinase-1 and may as well involve the p38 mitogen-activated protein kinases and the c-Jun N-terminal kinase signaling pathways. This primary research has manifested and encouraged the anticancer properties of dried longan seed extracts with potential inhibitory effects on cancer cell invasion as well as antigelatinase activity and expression in colon cancer cells. © 2013 American Chemical Society. 2018-04-25T08:46:34Z 2018-04-25T08:46:34Z 2013-04-17 Journal 15205118 00218561 2-s2.0-84876491871 10.1021/jf3052863 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876491871&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48006
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description The critical step in colorectal cancer progression and associated mortality is cancer invasion, which depends on two key gelatinase enzymes, matrix metalloproteinases-2 and -9. Dried longan (Euphoria longana Lam.) seed is a rich natural source of antioxidant polyphenols.This study evaluated the effect of dried longan seeds on colon cancer cell invasion via gelatinase function and expression. Three dried longan seed fractions were collected by Sephadex LH-20 column chromatography. They showed a potent inhibitor on colorectal cancer cell invasion and gelatinase activity. The antigelatinase activities of fractions 1 and 2 were a direct effect via Zn 2+ chelation, whereas fraction 3 modulated indirectly through suppression of zymogen activators. Among the fractions, only fraction 3 reduced the gelatinase expression, which was correlated with the levels of tissue inhibitor of metalloproteinase-1 and may as well involve the p38 mitogen-activated protein kinases and the c-Jun N-terminal kinase signaling pathways. This primary research has manifested and encouraged the anticancer properties of dried longan seed extracts with potential inhibitory effects on cancer cell invasion as well as antigelatinase activity and expression in colon cancer cells. © 2013 American Chemical Society.
format Journal
author Atita Panyathep
Teera Chewonarin
Khanittha Taneyhill
Usanee Vinitketkumnuen
Young Joon Surh
spellingShingle Atita Panyathep
Teera Chewonarin
Khanittha Taneyhill
Usanee Vinitketkumnuen
Young Joon Surh
Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
author_facet Atita Panyathep
Teera Chewonarin
Khanittha Taneyhill
Usanee Vinitketkumnuen
Young Joon Surh
author_sort Atita Panyathep
title Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
title_short Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
title_full Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
title_fullStr Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
title_full_unstemmed Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells
title_sort inhibitory effects of dried longan (euphoria longana lam.) seed extract on invasion and matrix metalloproteinases of colon cancer cells
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84876491871&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48006
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