Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy

Objective To evaluate disease-free survival (DFS) after radical hysterectomy and pelvic lymphadenectomy (RHPL) among early-stage cervical cancer patients with single-node involvement versus patients with no nodal involvement. Methods A retrospective review was conducted of the medical records of 843...

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Main Authors: Prapaporn Suprasert, Kittipat Charoenkwan, Sitthicha Siriaree, Chalong Cheewakriangkrai, Jaruwan Saeteng, Jatupol Srisomboon
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/48166
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-481662018-04-25T08:48:24Z Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy Prapaporn Suprasert Kittipat Charoenkwan Sitthicha Siriaree Chalong Cheewakriangkrai Jaruwan Saeteng Jatupol Srisomboon Objective To evaluate disease-free survival (DFS) after radical hysterectomy and pelvic lymphadenectomy (RHPL) among early-stage cervical cancer patients with single-node involvement versus patients with no nodal involvement. Methods A retrospective review was conducted of the medical records of 843 patients undergoing RHPL at Chiang Mai University Hospital, Thailand, between January 1, 2002, and December 31, 2008. Neoadjuvant chemotherapy was administered when the operative schedule was more than 1 month after diagnosis and adjuvant chemoradiation was administered to high-risk patients. Five subgroups were defined on the basis of pelvic node involvement: group A (0 nodes; n = 706), group B (1 node; n = 65), group C (2 nodes; n = 38), group D (3 nodes; n = 13), and group E (≥ 4 nodes; n = 21). Results The 5-year DFS was comparable for groups A and B (94.3% versus 92.1%; P = 0.454). In groups C, D, and E, the 5-year DFS was 85.9%, 75.0%, and 61.8%, respectively. The survival outcomes for groups A and B were significantly different from those of the other 3 groups (P < 0.001). Conclusion Cervical cancer patients with single-node involvement had comparable survival outcomes to those without nodal metastases; however, patients with multiple node involvement had reduced DFS. © 2012 International Federation of Gynecology and Obstetrics. 2018-04-25T08:48:24Z 2018-04-25T08:48:24Z 2013-01-01 Journal 18793479 00207292 2-s2.0-84875216921 10.1016/j.ijgo.2012.11.010 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875216921&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48166
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description Objective To evaluate disease-free survival (DFS) after radical hysterectomy and pelvic lymphadenectomy (RHPL) among early-stage cervical cancer patients with single-node involvement versus patients with no nodal involvement. Methods A retrospective review was conducted of the medical records of 843 patients undergoing RHPL at Chiang Mai University Hospital, Thailand, between January 1, 2002, and December 31, 2008. Neoadjuvant chemotherapy was administered when the operative schedule was more than 1 month after diagnosis and adjuvant chemoradiation was administered to high-risk patients. Five subgroups were defined on the basis of pelvic node involvement: group A (0 nodes; n = 706), group B (1 node; n = 65), group C (2 nodes; n = 38), group D (3 nodes; n = 13), and group E (≥ 4 nodes; n = 21). Results The 5-year DFS was comparable for groups A and B (94.3% versus 92.1%; P = 0.454). In groups C, D, and E, the 5-year DFS was 85.9%, 75.0%, and 61.8%, respectively. The survival outcomes for groups A and B were significantly different from those of the other 3 groups (P < 0.001). Conclusion Cervical cancer patients with single-node involvement had comparable survival outcomes to those without nodal metastases; however, patients with multiple node involvement had reduced DFS. © 2012 International Federation of Gynecology and Obstetrics.
format Journal
author Prapaporn Suprasert
Kittipat Charoenkwan
Sitthicha Siriaree
Chalong Cheewakriangkrai
Jaruwan Saeteng
Jatupol Srisomboon
spellingShingle Prapaporn Suprasert
Kittipat Charoenkwan
Sitthicha Siriaree
Chalong Cheewakriangkrai
Jaruwan Saeteng
Jatupol Srisomboon
Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
author_facet Prapaporn Suprasert
Kittipat Charoenkwan
Sitthicha Siriaree
Chalong Cheewakriangkrai
Jaruwan Saeteng
Jatupol Srisomboon
author_sort Prapaporn Suprasert
title Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
title_short Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
title_full Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
title_fullStr Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
title_full_unstemmed Outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
title_sort outcome of cervical cancer patients with single-node compared with no nodal involvement treated with radical hysterectomy and pelvic lymphadenectomy
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84875216921&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48166
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