Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21

© 2018 The Author(s). Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated with cognitive decline. However, the correlation between FGF21 and cognitive decline in elderly and nonelderly MetS patients has not been inv...

Full description

Saved in:
Bibliographic Details
Main Authors: Arintaya Phrommintikul, Piangkwan Sa-Nguanmoo, Jirapas Sripetchwandee, Prin Vathesatogkit, Nipon Chattipakorn, Siriporn C. Chattipakorn
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044503339&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48362
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-48362
record_format dspace
spelling th-cmuir.6653943832-483622018-04-25T10:11:29Z Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21 Arintaya Phrommintikul Piangkwan Sa-Nguanmoo Jirapas Sripetchwandee Prin Vathesatogkit Nipon Chattipakorn Siriporn C. Chattipakorn © 2018 The Author(s). Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated with cognitive decline. However, the correlation between FGF21 and cognitive decline in elderly and nonelderly MetS patients has not been investigated. 116 non-elderly patients (age < 65 years old) and 96 elderly patients (≥65 years old) with MetS were enrolled. Blood samples for FGF21 were collected from all participants after 12-hour fasting. Cognitive function was assessed using the Montreal cognitive assessment (MoCA) test. The MoCA score was negatively associated with age and was different among different levels of education in these MetS patients. In the non-elderly group, body mass index (BMI) showed positively correlated with MoCA score while, FGF21 level and HbA1C were negatively associated with the MoCA score in non-elderly MetS patients. BMI was the only factor which showed a negative correlation with the MoCA score in elderly MetS patients. This study demonstrated that FGF21 level was independently associated with cognitive impairment in non-elderly patients but not in elderly patients. The possible role of FGF21 level in cognitive impairment in non-elderly should be confirmed in a prospective study. 2018-04-25T10:11:29Z 2018-04-25T10:11:29Z 2018-12-01 Journal 20452322 2-s2.0-85044503339 10.1038/s41598-018-23550-9 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044503339&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48362
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2018 The Author(s). Increased fibroblast growth factor 21 (FGF21) levels have been found in patients with metabolic syndrome (MetS). MetS is also associated with cognitive decline. However, the correlation between FGF21 and cognitive decline in elderly and nonelderly MetS patients has not been investigated. 116 non-elderly patients (age < 65 years old) and 96 elderly patients (≥65 years old) with MetS were enrolled. Blood samples for FGF21 were collected from all participants after 12-hour fasting. Cognitive function was assessed using the Montreal cognitive assessment (MoCA) test. The MoCA score was negatively associated with age and was different among different levels of education in these MetS patients. In the non-elderly group, body mass index (BMI) showed positively correlated with MoCA score while, FGF21 level and HbA1C were negatively associated with the MoCA score in non-elderly MetS patients. BMI was the only factor which showed a negative correlation with the MoCA score in elderly MetS patients. This study demonstrated that FGF21 level was independently associated with cognitive impairment in non-elderly patients but not in elderly patients. The possible role of FGF21 level in cognitive impairment in non-elderly should be confirmed in a prospective study.
format Journal
author Arintaya Phrommintikul
Piangkwan Sa-Nguanmoo
Jirapas Sripetchwandee
Prin Vathesatogkit
Nipon Chattipakorn
Siriporn C. Chattipakorn
spellingShingle Arintaya Phrommintikul
Piangkwan Sa-Nguanmoo
Jirapas Sripetchwandee
Prin Vathesatogkit
Nipon Chattipakorn
Siriporn C. Chattipakorn
Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
author_facet Arintaya Phrommintikul
Piangkwan Sa-Nguanmoo
Jirapas Sripetchwandee
Prin Vathesatogkit
Nipon Chattipakorn
Siriporn C. Chattipakorn
author_sort Arintaya Phrommintikul
title Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
title_short Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
title_full Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
title_fullStr Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
title_full_unstemmed Factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: The different roles of FGF21
title_sort factors associated with cognitive impairment in elderly versus nonelderly patients with metabolic syndrome: the different roles of fgf21
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044503339&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48362
_version_ 1681423235053256704