Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice

© 2018, Chiang Mai University. High-fat diets are a well-known risk factor for many diseases, but the correlation between consuming a high-fat diet, serum lipid levels and the severity of depression or depression-like behavior remains unclear. Therefore, this study aimed to determine the effect of a...

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Main Authors: Jutamas Ruanpang, Apisate Pleumsamran, Juntima Pleumsamran, Salin Mingmalairak
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045335205&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48425
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spelling th-cmuir.6653943832-484252018-04-25T10:12:13Z Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice Jutamas Ruanpang Apisate Pleumsamran Juntima Pleumsamran Salin Mingmalairak © 2018, Chiang Mai University. High-fat diets are a well-known risk factor for many diseases, but the correlation between consuming a high-fat diet, serum lipid levels and the severity of depression or depression-like behavior remains unclear. Therefore, this study aimed to determine the effect of a high-fat diet on depression-like behavior and determine the correlation between cholesterol levels and the severity of depressive-like behavior. Thirty-nine, adult, male, C57BL/6Mlac mice were either fed a high-fat (61% of calories from fat) or normal (11% of calories from fat) diet for 10 weeks. At the end of the experiment, serum cholesterol levels and depression-like behavior, as determined by the forced swimming and tail suspension tests, were compared between the mice fed normal (control) and high-fat diets. The mice fed the high-fat diet showed significantly higher total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels, as well as significantly longer immobility times in the forced swimming test (but not the tail suspension test), compared to the control group; thus, we concluded that consuming a high-fat diet for 10 weeks increased serum cholesterol and triglyceride levels and produced depression-like behavior in mice. In the mice fed the high-fat diet, we found large positive correlations between both total cholesterol and HDL-C levels with immobility times during the forced swimming test, indicating a strong link between hyperlipidemia and depressionlike behaviors in mice. 2018-04-25T10:12:13Z 2018-04-25T10:12:13Z 2018-04-01 Journal 16851994 2-s2.0-85045335205 10.12982/CMUJNS.2018.0012 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045335205&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48425
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © 2018, Chiang Mai University. High-fat diets are a well-known risk factor for many diseases, but the correlation between consuming a high-fat diet, serum lipid levels and the severity of depression or depression-like behavior remains unclear. Therefore, this study aimed to determine the effect of a high-fat diet on depression-like behavior and determine the correlation between cholesterol levels and the severity of depressive-like behavior. Thirty-nine, adult, male, C57BL/6Mlac mice were either fed a high-fat (61% of calories from fat) or normal (11% of calories from fat) diet for 10 weeks. At the end of the experiment, serum cholesterol levels and depression-like behavior, as determined by the forced swimming and tail suspension tests, were compared between the mice fed normal (control) and high-fat diets. The mice fed the high-fat diet showed significantly higher total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride levels, as well as significantly longer immobility times in the forced swimming test (but not the tail suspension test), compared to the control group; thus, we concluded that consuming a high-fat diet for 10 weeks increased serum cholesterol and triglyceride levels and produced depression-like behavior in mice. In the mice fed the high-fat diet, we found large positive correlations between both total cholesterol and HDL-C levels with immobility times during the forced swimming test, indicating a strong link between hyperlipidemia and depressionlike behaviors in mice.
format Journal
author Jutamas Ruanpang
Apisate Pleumsamran
Juntima Pleumsamran
Salin Mingmalairak
spellingShingle Jutamas Ruanpang
Apisate Pleumsamran
Juntima Pleumsamran
Salin Mingmalairak
Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
author_facet Jutamas Ruanpang
Apisate Pleumsamran
Juntima Pleumsamran
Salin Mingmalairak
author_sort Jutamas Ruanpang
title Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
title_short Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
title_full Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
title_fullStr Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
title_full_unstemmed Effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
title_sort effect of a high-fat diet and cholesterol levels on depression-like behavior in mice
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045335205&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48425
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