Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases

© American Society for Clinical Pathology 2018. All rights reserved. Objectives To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods Samples of 43 delet...

Full description

Saved in:
Bibliographic Details
Main Authors: Sakorn Pornprasert, Nur Afsan Salaeh, Monthathip Tookjai, Manoo Punyamung, Panida Pongpunyayuen, Kallayanee Treesuwan
Format: Journal
Published: 2018
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044632102&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48464
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-48464
record_format dspace
spelling th-cmuir.6653943832-484642018-04-25T10:12:46Z Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases Sakorn Pornprasert Nur Afsan Salaeh Monthathip Tookjai Manoo Punyamung Panida Pongpunyayuen Kallayanee Treesuwan © American Society for Clinical Pathology 2018. All rights reserved. Objectives To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods Samples of 43 deletional HbH diseases, which included 39 - SEA /-α 3.7, 4 - - SEA /-α 4.2, and 22 nondeletional HbH diseases (- - SEA /α cs α), were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed. Results The deletional HbH disease had higher levels of RBC counts, total Hb, pack cell volume (PCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), HbA, and HbA 2 than did the nondeletional HbH disease. A negative correlation between HbH and RBC counts was detected in the group of deletional HbH disease, while a positive correlation between HbH and RBC counts, total Hb, and PCV was found in the group of nondeletional HbH disease. Conclusions These results reflected that samples with nondeletional HbH showed more anemic features than those with the deletional HbH. 2018-04-25T10:12:46Z 2018-04-25T10:12:46Z 2018-03-21 Journal 19437730 00075027 2-s2.0-85044632102 10.1093/labmed/lmx068 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044632102&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48464
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
description © American Society for Clinical Pathology 2018. All rights reserved. Objectives To compare hematological parameters between deletional and nondeletional HbH diseases, and to investigate the correlation between HbH levels and hematological parameters within these 2 groups. Methods Samples of 43 deletional HbH diseases, which included 39 - SEA /-α 3.7, 4 - - SEA /-α 4.2, and 22 nondeletional HbH diseases (- - SEA /α cs α), were used in this study. Correlations between HbH levels and hematological parameters within these 2 groups were analyzed. Results The deletional HbH disease had higher levels of RBC counts, total Hb, pack cell volume (PCV), mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), HbA, and HbA 2 than did the nondeletional HbH disease. A negative correlation between HbH and RBC counts was detected in the group of deletional HbH disease, while a positive correlation between HbH and RBC counts, total Hb, and PCV was found in the group of nondeletional HbH disease. Conclusions These results reflected that samples with nondeletional HbH showed more anemic features than those with the deletional HbH.
format Journal
author Sakorn Pornprasert
Nur Afsan Salaeh
Monthathip Tookjai
Manoo Punyamung
Panida Pongpunyayuen
Kallayanee Treesuwan
spellingShingle Sakorn Pornprasert
Nur Afsan Salaeh
Monthathip Tookjai
Manoo Punyamung
Panida Pongpunyayuen
Kallayanee Treesuwan
Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
author_facet Sakorn Pornprasert
Nur Afsan Salaeh
Monthathip Tookjai
Manoo Punyamung
Panida Pongpunyayuen
Kallayanee Treesuwan
author_sort Sakorn Pornprasert
title Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
title_short Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
title_full Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
title_fullStr Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
title_full_unstemmed Hematological Analysis in Thai Samples with Deletional and Nondeletional HbH Diseases
title_sort hematological analysis in thai samples with deletional and nondeletional hbh diseases
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85044632102&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48464
_version_ 1681423253795504128