Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach
Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methac...
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th-cmuir.6653943832-488392018-08-16T02:07:15Z Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach Weeranuch Kareuhanon Vannajan Sanghiran Lee Piyarat Nimmanpipug Chatchai Tayapiwatana Mookda Pattarawarapan Biochemistry, Genetics and Molecular Biology Chemistry Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methacrylic acid (MAA) monomer and the selected templates, while equilibrium binding studies were applied to evaluate the polymer binding efficiency. The data indicated that NAM is the best candidate to prepare MIPs for retaining NVP due to a relatively similar binding energy between the NVP-MAA and NAM-MAA complex. The NAM-imprinted polymer showed a high binding affinity and selectivity toward NVP. When the polymer was applied as a sorbent in solid-phase extraction of NVP from human plasma, high recovery and reproducibility were obtained. © 2009 Vieweg+Teubner | GWV Fachverlage GmbH. 2018-08-16T02:05:39Z 2018-08-16T02:05:39Z 2009-12-01 Journal 16121112 00095893 2-s2.0-72349096643 10.1365/s10337-009-1385-4 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=72349096643&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48839 |
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Biochemistry, Genetics and Molecular Biology Chemistry Weeranuch Kareuhanon Vannajan Sanghiran Lee Piyarat Nimmanpipug Chatchai Tayapiwatana Mookda Pattarawarapan Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
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Nevirapine (NVP) and its structurally related analogs including nicotinamide (NAM), benzamide (BZM) and benzophenone (BZP) were used as templates in the synthesis of molecularly imprinted polymers for NVP. Molecular modeling was used to estimate binding energy of the complex formation between methacrylic acid (MAA) monomer and the selected templates, while equilibrium binding studies were applied to evaluate the polymer binding efficiency. The data indicated that NAM is the best candidate to prepare MIPs for retaining NVP due to a relatively similar binding energy between the NVP-MAA and NAM-MAA complex. The NAM-imprinted polymer showed a high binding affinity and selectivity toward NVP. When the polymer was applied as a sorbent in solid-phase extraction of NVP from human plasma, high recovery and reproducibility were obtained. © 2009 Vieweg+Teubner | GWV Fachverlage GmbH. |
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author |
Weeranuch Kareuhanon Vannajan Sanghiran Lee Piyarat Nimmanpipug Chatchai Tayapiwatana Mookda Pattarawarapan |
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Weeranuch Kareuhanon Vannajan Sanghiran Lee Piyarat Nimmanpipug Chatchai Tayapiwatana Mookda Pattarawarapan |
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Weeranuch Kareuhanon |
title |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
title_short |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
title_full |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
title_fullStr |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
title_full_unstemmed |
Synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
title_sort |
synthesis of molecularly imprinted polymers for nevirapine by dummy template imprinting approach |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=72349096643&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48839 |
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