Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications

Drug delivery systems using vesicular carriers such as liposomes or niosomes, have distinct advantages over conventional dosage forms because the vesicles can act as drug containing reservoirs and the modification of the vesicular compositions or surface properties can adjust the drug release rate a...

Full description

Saved in:
Bibliographic Details
Main Authors: Aranya Manosroi, Pensak Jantrawut, Narinthorn Khositsuntiwong, Worapaka Manosroi, Jiradej Manosroi
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650686770&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48879
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-48879
record_format dspace
spelling th-cmuir.6653943832-488792018-08-16T02:18:17Z Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications Aranya Manosroi Pensak Jantrawut Narinthorn Khositsuntiwong Worapaka Manosroi Jiradej Manosroi Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy Drug delivery systems using vesicular carriers such as liposomes or niosomes, have distinct advantages over conventional dosage forms because the vesicles can act as drug containing reservoirs and the modification of the vesicular compositions or surface properties can adjust the drug release rate and/or the affinity for the target site. The optimized elastic niosomal formulations for the topical non-invasive treatment of gene therapy and local pain or inflammation have been developed. The gel containing the novel Tween 61 elastic niosomes entrapped with DCFD (diclofenac diethylammonium) did not only show physical and chemical stability for 3 months, but also high fluxes through rat skin and high in vivo anti-inflammatory activity in rat ear edema assay. This optimized developed gel can offer a promising formulation for DCFD in the topical non-invasive treatment of inflammation. The enhancement of transdermal absorption of luciferase plasmid (pLuc) by entrapping in non-elastic vesicular formulations together with the application of the stratum corneum (SC) stripping and iontophoresis technique as well as the entrapment in elastic nanovesicles has also demonstrated. The elastic vesicles even without any application techniques can enhance the transdermal absorption of the plasmid. The pLuc entrapped in elastic niosomes gave higher fluxes than elastic liposomes, but no significance. The superior through skin delivery of pLuc by entrapping in niosomes with the application of iontophoresis can be used as a technique to deliver genetic materials via topical administration in gene therapy. However, although pLuc entrapped in elastic nanovesicles gave lesser fluxes than by iontophoresis application on the pLuc entrapped in non-elastic vesicles, elastic vesicles appeared to be a more promising approach with more practical use for topical gene delivery than the iontophoresis technique since no additional equipment is required. 2018-08-16T02:06:11Z 2018-08-16T02:06:11Z 2009-05-01 Journal 01252526 2-s2.0-67650686770 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650686770&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48879
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Materials Science
Mathematics
Physics and Astronomy
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Materials Science
Mathematics
Physics and Astronomy
Aranya Manosroi
Pensak Jantrawut
Narinthorn Khositsuntiwong
Worapaka Manosroi
Jiradej Manosroi
Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
description Drug delivery systems using vesicular carriers such as liposomes or niosomes, have distinct advantages over conventional dosage forms because the vesicles can act as drug containing reservoirs and the modification of the vesicular compositions or surface properties can adjust the drug release rate and/or the affinity for the target site. The optimized elastic niosomal formulations for the topical non-invasive treatment of gene therapy and local pain or inflammation have been developed. The gel containing the novel Tween 61 elastic niosomes entrapped with DCFD (diclofenac diethylammonium) did not only show physical and chemical stability for 3 months, but also high fluxes through rat skin and high in vivo anti-inflammatory activity in rat ear edema assay. This optimized developed gel can offer a promising formulation for DCFD in the topical non-invasive treatment of inflammation. The enhancement of transdermal absorption of luciferase plasmid (pLuc) by entrapping in non-elastic vesicular formulations together with the application of the stratum corneum (SC) stripping and iontophoresis technique as well as the entrapment in elastic nanovesicles has also demonstrated. The elastic vesicles even without any application techniques can enhance the transdermal absorption of the plasmid. The pLuc entrapped in elastic niosomes gave higher fluxes than elastic liposomes, but no significance. The superior through skin delivery of pLuc by entrapping in niosomes with the application of iontophoresis can be used as a technique to deliver genetic materials via topical administration in gene therapy. However, although pLuc entrapped in elastic nanovesicles gave lesser fluxes than by iontophoresis application on the pLuc entrapped in non-elastic vesicles, elastic vesicles appeared to be a more promising approach with more practical use for topical gene delivery than the iontophoresis technique since no additional equipment is required.
format Journal
author Aranya Manosroi
Pensak Jantrawut
Narinthorn Khositsuntiwong
Worapaka Manosroi
Jiradej Manosroi
author_facet Aranya Manosroi
Pensak Jantrawut
Narinthorn Khositsuntiwong
Worapaka Manosroi
Jiradej Manosroi
author_sort Aranya Manosroi
title Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
title_short Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
title_full Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
title_fullStr Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
title_full_unstemmed Novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
title_sort novel elastic nanovesicles for cosmeceutical and pharmaceutical applications
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650686770&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48879
_version_ 1681423309550387200