Versican/PG-M assembles hyaluronan into extracellular matrix and inhibits CD44-mediated signaling toward premature senescence in embryonic fibroblasts

• Main Authors: Keittisak Suwan, Kanyamas Choocheep, Sonoko Hatano, Prachya Kongtawelert, Koji Kimata, Hideto Watanabe
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67649760194&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/48893
• Institution: Chiang Mai University

Versican/PG-M is a large chondroitin sulfate proteoglycan of the extracellular matrix which interacts with hyaluronan at the N-terminal G1 domain, composed of A, B, and B′ subdomains. Recently, we generated knock-in mice Cspg23/3, whose versican, without the A subdomain, has decreased hyaluronan (HA...