The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries

Worldwide, there are 2.1 million children under 15 years of age living with HIV infection. In the past five years, there has been significant progress in providing antiretroviral therapy (ART) to children in resourcelimited countries. According to the World Health Organization, an estimated 200,000...

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Main Authors: Torsak Bunupuradah, Linda Aurpibul, Jintanat Ananworanich, Thanyawee Puthanakit
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/48902
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-489022018-08-16T02:15:38Z The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries Torsak Bunupuradah Linda Aurpibul Jintanat Ananworanich Thanyawee Puthanakit Biochemistry, Genetics and Molecular Biology Medicine Worldwide, there are 2.1 million children under 15 years of age living with HIV infection. In the past five years, there has been significant progress in providing antiretroviral therapy (ART) to children in resourcelimited countries. According to the World Health Organization, an estimated 200,000 children were receiving ART by the end of 2007. Objective: To conduct a general review of pediatric ART effectiveness in Asian countries. Methods: Published articles in PubMed and abstracts from the international HIV conferences were searched for articles related to pediatric ART in Asian countries from 1999 up to 2008. Results: Available reports consistently demonstrated beneficial outcomes of first-line antiretroviral therapy, including significant reductions in mortality and hospitalization rates, and good immunological and virological outcomes. However, there were limited data on the availability of second- line ART and the management of children who failed first-line regimens. There was also a need for improved access to early diagnostic testing and treatment in infancy, and more data on ART selection for children exposed to antiretrovirals for prevention of mother to child transmission. Conclusion: The highly active antiretroviral therapy is effective among HIV-infected children in Asia. Strategies for improved diagnosis and implementation of the life-saving antiretroviral programs including second -line ART, throughout Asia is encouraged. 2018-08-16T02:06:30Z 2018-08-16T02:06:30Z 2009-02-01 Journal 19057415 2-s2.0-70349392049 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349392049&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48902
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Torsak Bunupuradah
Linda Aurpibul
Jintanat Ananworanich
Thanyawee Puthanakit
The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
description Worldwide, there are 2.1 million children under 15 years of age living with HIV infection. In the past five years, there has been significant progress in providing antiretroviral therapy (ART) to children in resourcelimited countries. According to the World Health Organization, an estimated 200,000 children were receiving ART by the end of 2007. Objective: To conduct a general review of pediatric ART effectiveness in Asian countries. Methods: Published articles in PubMed and abstracts from the international HIV conferences were searched for articles related to pediatric ART in Asian countries from 1999 up to 2008. Results: Available reports consistently demonstrated beneficial outcomes of first-line antiretroviral therapy, including significant reductions in mortality and hospitalization rates, and good immunological and virological outcomes. However, there were limited data on the availability of second- line ART and the management of children who failed first-line regimens. There was also a need for improved access to early diagnostic testing and treatment in infancy, and more data on ART selection for children exposed to antiretrovirals for prevention of mother to child transmission. Conclusion: The highly active antiretroviral therapy is effective among HIV-infected children in Asia. Strategies for improved diagnosis and implementation of the life-saving antiretroviral programs including second -line ART, throughout Asia is encouraged.
format Journal
author Torsak Bunupuradah
Linda Aurpibul
Jintanat Ananworanich
Thanyawee Puthanakit
author_facet Torsak Bunupuradah
Linda Aurpibul
Jintanat Ananworanich
Thanyawee Puthanakit
author_sort Torsak Bunupuradah
title The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
title_short The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
title_full The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
title_fullStr The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
title_full_unstemmed The effectiveness of highly active antiretroviral therapy among HIV-infected children in Asian countries
title_sort effectiveness of highly active antiretroviral therapy among hiv-infected children in asian countries
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70349392049&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/48902
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