Gastroprotective activity of padina minor yamada
Padina minor Yamada, a brown alga which is found to be abundant on both sides of the coastal area of the gulf of Thailand and the Andaman Sea was examined for gastroprotective activity. The aqueous extract of P. minor (Aq. P) given orally to rats at the doses of 100, 200 and 500 mg/kg significantly...
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th-cmuir.6653943832-489202018-08-16T02:18:39Z Gastroprotective activity of padina minor yamada Doungporn Amornlerdpison Yuwadee Peerapornpisal Tawat Taesotikul Thidarat Noiraksar Duangta Kanjanapothi Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy Padina minor Yamada, a brown alga which is found to be abundant on both sides of the coastal area of the gulf of Thailand and the Andaman Sea was examined for gastroprotective activity. The aqueous extract of P. minor (Aq. P) given orally to rats at the doses of 100, 200 and 500 mg/kg significantly inhibited gastric ulcer formation induced by (1) restraint water immersion stress (2) acid ethanol (HCl /EtOH), (3) indomethacin and (4) histamine. In the pylorus-ligated rat experiment, the Aq. P caused a decrease of the total acidity and an increase in gastric pH. Additionally, the Aq. P could not preserve the mucus content in the gastric wall of rats with gastric ulceration induced by HCl /EtOH. Results were obtained from the isolated guinea-pig right atrium experiment of which the inhibitory effects of cimetidine (Histamine H2-antagonist) and the Aq. P on histamine-induced chronotropic responses were determined and these results suggest that they share a similar mechanism. The findings therefore indicate that P. minor possesses a gastroprotective activity, which involves an anti-secretory mechanism mediated via histamine H 2-antagonism. The polysaccharide present in the P. minor is likely to contribute to the gastroprotective activity. 2018-08-16T02:06:39Z 2018-08-16T02:06:39Z 2009-01-01 Journal 01252526 2-s2.0-67650314463 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650314463&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48920 |
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Biochemistry, Genetics and Molecular Biology Chemistry Materials Science Mathematics Physics and Astronomy Doungporn Amornlerdpison Yuwadee Peerapornpisal Tawat Taesotikul Thidarat Noiraksar Duangta Kanjanapothi Gastroprotective activity of padina minor yamada |
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Padina minor Yamada, a brown alga which is found to be abundant on both sides of the coastal area of the gulf of Thailand and the Andaman Sea was examined for gastroprotective activity. The aqueous extract of P. minor (Aq. P) given orally to rats at the doses of 100, 200 and 500 mg/kg significantly inhibited gastric ulcer formation induced by (1) restraint water immersion stress (2) acid ethanol (HCl /EtOH), (3) indomethacin and (4) histamine. In the pylorus-ligated rat experiment, the Aq. P caused a decrease of the total acidity and an increase in gastric pH. Additionally, the Aq. P could not preserve the mucus content in the gastric wall of rats with gastric ulceration induced by HCl /EtOH. Results were obtained from the isolated guinea-pig right atrium experiment of which the inhibitory effects of cimetidine (Histamine H2-antagonist) and the Aq. P on histamine-induced chronotropic responses were determined and these results suggest that they share a similar mechanism. The findings therefore indicate that P. minor possesses a gastroprotective activity, which involves an anti-secretory mechanism mediated via histamine H 2-antagonism. The polysaccharide present in the P. minor is likely to contribute to the gastroprotective activity. |
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Doungporn Amornlerdpison Yuwadee Peerapornpisal Tawat Taesotikul Thidarat Noiraksar Duangta Kanjanapothi |
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Doungporn Amornlerdpison Yuwadee Peerapornpisal Tawat Taesotikul Thidarat Noiraksar Duangta Kanjanapothi |
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Doungporn Amornlerdpison |
title |
Gastroprotective activity of padina minor yamada |
title_short |
Gastroprotective activity of padina minor yamada |
title_full |
Gastroprotective activity of padina minor yamada |
title_fullStr |
Gastroprotective activity of padina minor yamada |
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Gastroprotective activity of padina minor yamada |
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gastroprotective activity of padina minor yamada |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650314463&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/48920 |
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