Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome

Background: Peutz-Jeghers Syndrome (PJS) is a rare genetic disorder characterized by mucocutaneous melanin deposition, and intestinal hamartomatous polyps, with an increased risk of breast, gastrointestinal, and female genital tract cancers. Case Report: Multiple genital tract neoplasms in a 52-year...

Full description

Saved in:
Bibliographic Details
Main Authors: Charuwan Tantipalakorn, Surapan Khunamornpong, Nirush Lertprasertsuke, Theera Tongsong
Format: Journal
Published: 2018
Subjects:
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77249118238&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49269
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-49269
record_format dspace
spelling th-cmuir.6653943832-492692018-08-16T02:13:37Z Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome Charuwan Tantipalakorn Surapan Khunamornpong Nirush Lertprasertsuke Theera Tongsong Medicine Background: Peutz-Jeghers Syndrome (PJS) is a rare genetic disorder characterized by mucocutaneous melanin deposition, and intestinal hamartomatous polyps, with an increased risk of breast, gastrointestinal, and female genital tract cancers. Case Report: Multiple genital tract neoplasms in a 52-year-old northern Thai woman with PJS are described. The patient presented with abdominal distention. A pelvic ultrasound scan showed a left adnexal mass, diagnosed as mucinous cyst. An ovarian microscopic cystadenoma was diagnosed together with a minimal deviation mucinous adenocarcinoma (MDA) of the uterine cervix and mucinous metaplasia in tubal mucosa and endometrium. Pathological findings warranted a search for evidence of PJS. Typical pigmentation at the hard palate and colonoscopic finding of hamartomatous polyps established the diagnosis of PJS. At four-year follow-up, the patient still showed no evidence of tumor recurrence. Conclusion: A case of PJS complicated by multiple and contemporaneous genital tract tumors with rare histological findings is presented. The presented case suggests MDA and mucinous metaplasia warrant a search for PJS. 2018-08-16T02:13:37Z 2018-08-16T02:13:37Z 2009-12-01 Journal 01252208 01252208 2-s2.0-77249118238 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77249118238&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49269
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Charuwan Tantipalakorn
Surapan Khunamornpong
Nirush Lertprasertsuke
Theera Tongsong
Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
description Background: Peutz-Jeghers Syndrome (PJS) is a rare genetic disorder characterized by mucocutaneous melanin deposition, and intestinal hamartomatous polyps, with an increased risk of breast, gastrointestinal, and female genital tract cancers. Case Report: Multiple genital tract neoplasms in a 52-year-old northern Thai woman with PJS are described. The patient presented with abdominal distention. A pelvic ultrasound scan showed a left adnexal mass, diagnosed as mucinous cyst. An ovarian microscopic cystadenoma was diagnosed together with a minimal deviation mucinous adenocarcinoma (MDA) of the uterine cervix and mucinous metaplasia in tubal mucosa and endometrium. Pathological findings warranted a search for evidence of PJS. Typical pigmentation at the hard palate and colonoscopic finding of hamartomatous polyps established the diagnosis of PJS. At four-year follow-up, the patient still showed no evidence of tumor recurrence. Conclusion: A case of PJS complicated by multiple and contemporaneous genital tract tumors with rare histological findings is presented. The presented case suggests MDA and mucinous metaplasia warrant a search for PJS.
format Journal
author Charuwan Tantipalakorn
Surapan Khunamornpong
Nirush Lertprasertsuke
Theera Tongsong
author_facet Charuwan Tantipalakorn
Surapan Khunamornpong
Nirush Lertprasertsuke
Theera Tongsong
author_sort Charuwan Tantipalakorn
title Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
title_short Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
title_full Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
title_fullStr Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
title_full_unstemmed Female genital tract tumors and gastrointestinal lesions in the Peutz-Jeghers Syndrome
title_sort female genital tract tumors and gastrointestinal lesions in the peutz-jeghers syndrome
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77249118238&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49269
_version_ 1681423379608895488