Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women

• Main Authors: Soranun Chantarangsu, Tim R. Cressey, Surakameth Mahasirimongkol, Edmund Capparelli, Yardpiroon Tawon, Nicole Ngo-Giang-Huong, Gonzague Jourdain, Marc Lallemant, Wasun Chantratita
• Format: Journal
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=73549117428&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49291
• Institution: Chiang Mai University

Objectives: To investigate the association of single nucleotide polymorphisms (SNPs) with nevirapine concentrations following intra-partum single-dose nevirapine. Methods: Plasma and DNA samples were obtained from 330 HIV-infected Thai women who received intra-partum single-dose nevirapine in the PH...