Urinary pesticide metabolites in school students from northern Thailand
We evaluated exposure to pesticides among secondary school students aged 12-13 years old in Chiang Mai Province, Thailand. Pesticide-specific urinary metabolites were used as biomarkers of exposure for a variety of pesticides, including organophosphorus insecticides, synthetic pyrethroid insecticide...
Saved in:
Main Authors: | , , , |
---|---|
Format: | Journal |
Published: |
2018
|
Subjects: | |
Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62649105643&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49350 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
id |
th-cmuir.6653943832-49350 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-493502018-08-16T02:15:01Z Urinary pesticide metabolites in school students from northern Thailand Parinya Panuwet Tippawan Prapamontol Somporn Chantara Dana B. Barr Medicine We evaluated exposure to pesticides among secondary school students aged 12-13 years old in Chiang Mai Province, Thailand. Pesticide-specific urinary metabolites were used as biomarkers of exposure for a variety of pesticides, including organophosphorus insecticides, synthetic pyrethroid insecticides and selected herbicides. We employed a simple solid-phase extraction with analysis using isotope dilution high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). A total of 207 urine samples from Thai students were analyzed for 18 specific pesticide metabolites. We found 14 metabolites in the urine samples tested; seven of them were detected with a frequency≥17%. The most frequently detected metabolites were 2-[(dimethoxyphosphorothioyl) sulfanyl] succinic acid (malathion dicarboxylic acid), para-nitrophenol (PNP), 3,5,6-trichloro-2-pyridinol (TPCY; metabolite of chlorpyrifos), 2,4-dichlorophenoxyacetic acid (2,4-D), cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (c-DCCA and t-DCCA; metabolite of permethrin) and 3-phenoxybenzoic acid (3-PBA; metabolite of pyrethroids). The students were classified into 4 groups according to their parental occupations: farmers (N=60), merchants and traders (N=39), government and company employees (N=52), and laborers (N=56). Children of farmers had significantly higher urinary concentrations of pyrethroid insecticide metabolites than did other children (p<0.05). Similarly, children of agricultural families had significantly higher pyrethroid metabolite concentrations. Males had significantly higher values of PNP (Mann-Whitney test, p=0.009); however, no other sex-related differences were observed. Because parental occupation and agricultural activities seemed to have little influence on pesticide levels, dietary sources were the likely contributors to the metabolite levels observed. © 2008 Elsevier GmbH. 2018-08-16T02:15:01Z 2018-08-16T02:15:01Z 2009-05-01 Journal 1618131X 14384639 2-s2.0-62649105643 10.1016/j.ijheh.2008.07.002 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62649105643&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49350 |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
topic |
Medicine |
spellingShingle |
Medicine Parinya Panuwet Tippawan Prapamontol Somporn Chantara Dana B. Barr Urinary pesticide metabolites in school students from northern Thailand |
description |
We evaluated exposure to pesticides among secondary school students aged 12-13 years old in Chiang Mai Province, Thailand. Pesticide-specific urinary metabolites were used as biomarkers of exposure for a variety of pesticides, including organophosphorus insecticides, synthetic pyrethroid insecticides and selected herbicides. We employed a simple solid-phase extraction with analysis using isotope dilution high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). A total of 207 urine samples from Thai students were analyzed for 18 specific pesticide metabolites. We found 14 metabolites in the urine samples tested; seven of them were detected with a frequency≥17%. The most frequently detected metabolites were 2-[(dimethoxyphosphorothioyl) sulfanyl] succinic acid (malathion dicarboxylic acid), para-nitrophenol (PNP), 3,5,6-trichloro-2-pyridinol (TPCY; metabolite of chlorpyrifos), 2,4-dichlorophenoxyacetic acid (2,4-D), cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (c-DCCA and t-DCCA; metabolite of permethrin) and 3-phenoxybenzoic acid (3-PBA; metabolite of pyrethroids). The students were classified into 4 groups according to their parental occupations: farmers (N=60), merchants and traders (N=39), government and company employees (N=52), and laborers (N=56). Children of farmers had significantly higher urinary concentrations of pyrethroid insecticide metabolites than did other children (p<0.05). Similarly, children of agricultural families had significantly higher pyrethroid metabolite concentrations. Males had significantly higher values of PNP (Mann-Whitney test, p=0.009); however, no other sex-related differences were observed. Because parental occupation and agricultural activities seemed to have little influence on pesticide levels, dietary sources were the likely contributors to the metabolite levels observed. © 2008 Elsevier GmbH. |
format |
Journal |
author |
Parinya Panuwet Tippawan Prapamontol Somporn Chantara Dana B. Barr |
author_facet |
Parinya Panuwet Tippawan Prapamontol Somporn Chantara Dana B. Barr |
author_sort |
Parinya Panuwet |
title |
Urinary pesticide metabolites in school students from northern Thailand |
title_short |
Urinary pesticide metabolites in school students from northern Thailand |
title_full |
Urinary pesticide metabolites in school students from northern Thailand |
title_fullStr |
Urinary pesticide metabolites in school students from northern Thailand |
title_full_unstemmed |
Urinary pesticide metabolites in school students from northern Thailand |
title_sort |
urinary pesticide metabolites in school students from northern thailand |
publishDate |
2018 |
url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=62649105643&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49350 |
_version_ |
1681423394154741760 |