Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand

Background: To investigate a possible interaction between α-thalassaemia, β-thalassaemia and haemoglobin-E trait and the haematological parameters of HIV type-1 (HIV-1)-infected pregnant women receiving zidovudine prophylaxis for the prevention of mother-to-child HIV-1 transmission in Thailand. Meth...

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Main Authors: Nelly Briand, Sakorn Pornprasert, Nicole Ngo-Giang-Huong, Fréderic Galactéros, Serge Pissara, Thanusak Tatu, Torpong Sanguansermsri, Gonzague Jourdoin, Marc Lallemant, Sophie Le Coeur
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49365
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spelling th-cmuir.6653943832-493652018-08-16T02:16:59Z Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand Nelly Briand Sakorn Pornprasert Nicole Ngo-Giang-Huong Fréderic Galactéros Serge Pissara Thanusak Tatu Torpong Sanguansermsri Gonzague Jourdoin Marc Lallemant Sophie Le Coeur Medicine Pharmacology, Toxicology and Pharmaceutics Background: To investigate a possible interaction between α-thalassaemia, β-thalassaemia and haemoglobin-E trait and the haematological parameters of HIV type-1 (HIV-1)-infected pregnant women receiving zidovudine prophylaxis for the prevention of mother-to-child HIV-1 transmission in Thailand. Methods: The study sample was composed of HIV-1-infected pregnant women receiving zidovudine (300 mg twice daily) from 28 weeks of gestational age to delivery as part of the Perinatal HIV Prevention Trial (PHPT-1), a large trial investigating zidovudine use in pregnancy. These women were randomly selected and screened for haemoglobin abnormalities. Haemoglobin levels, haermatocrit and erythrocyte, leukocyte, absolute neutrophil and absolute lymphocyte counts were measured at 26, 32 and 35 weeks of gestation and at delivery. PCR genotyping techniques were used to screen for haemoglobin abnormalities, which included α-thalassaemia-1 Southeast Asian type deletion, β-thalassaemia mutation (codons 41/42 [-TCTTT], codon 17 [A→T], intervening sequence-I nucleotide 1 [G→T], codons 71/72 [+A]) and haemoglobin-E trait. The evolution of haematological parameters between 26 weeks and delivery was compared according to thalassaemia carriage using linear mixed models adjusted for baseline sociodemographic characteristics, HIV clinical stage, CD4+ T-cell count and viral load. Results: At baseline, women with thalassaemia or haemoglobin-E trait had significantly lower haemoglobin level and red blood cell counts than women with no haemoglobin abnormalities, whereas absolute neutrophil and leukocyte counts were significantly higher. Exposure to zidovudine until delivery did not increase this difference. Conclusions: Zidovudine exposure did not appear to have increased haematological toxicity in HIV-1-infected pregnant women with thalassaemia. © 2009 International Medical Press. 2018-08-16T02:15:17Z 2018-08-16T02:15:17Z 2009-03-16 Journal 13596535 2-s2.0-61849158733 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=61849158733&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49365
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Medicine
Pharmacology, Toxicology and Pharmaceutics
Nelly Briand
Sakorn Pornprasert
Nicole Ngo-Giang-Huong
Fréderic Galactéros
Serge Pissara
Thanusak Tatu
Torpong Sanguansermsri
Gonzague Jourdoin
Marc Lallemant
Sophie Le Coeur
Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
description Background: To investigate a possible interaction between α-thalassaemia, β-thalassaemia and haemoglobin-E trait and the haematological parameters of HIV type-1 (HIV-1)-infected pregnant women receiving zidovudine prophylaxis for the prevention of mother-to-child HIV-1 transmission in Thailand. Methods: The study sample was composed of HIV-1-infected pregnant women receiving zidovudine (300 mg twice daily) from 28 weeks of gestational age to delivery as part of the Perinatal HIV Prevention Trial (PHPT-1), a large trial investigating zidovudine use in pregnancy. These women were randomly selected and screened for haemoglobin abnormalities. Haemoglobin levels, haermatocrit and erythrocyte, leukocyte, absolute neutrophil and absolute lymphocyte counts were measured at 26, 32 and 35 weeks of gestation and at delivery. PCR genotyping techniques were used to screen for haemoglobin abnormalities, which included α-thalassaemia-1 Southeast Asian type deletion, β-thalassaemia mutation (codons 41/42 [-TCTTT], codon 17 [A→T], intervening sequence-I nucleotide 1 [G→T], codons 71/72 [+A]) and haemoglobin-E trait. The evolution of haematological parameters between 26 weeks and delivery was compared according to thalassaemia carriage using linear mixed models adjusted for baseline sociodemographic characteristics, HIV clinical stage, CD4+ T-cell count and viral load. Results: At baseline, women with thalassaemia or haemoglobin-E trait had significantly lower haemoglobin level and red blood cell counts than women with no haemoglobin abnormalities, whereas absolute neutrophil and leukocyte counts were significantly higher. Exposure to zidovudine until delivery did not increase this difference. Conclusions: Zidovudine exposure did not appear to have increased haematological toxicity in HIV-1-infected pregnant women with thalassaemia. © 2009 International Medical Press.
format Journal
author Nelly Briand
Sakorn Pornprasert
Nicole Ngo-Giang-Huong
Fréderic Galactéros
Serge Pissara
Thanusak Tatu
Torpong Sanguansermsri
Gonzague Jourdoin
Marc Lallemant
Sophie Le Coeur
author_facet Nelly Briand
Sakorn Pornprasert
Nicole Ngo-Giang-Huong
Fréderic Galactéros
Serge Pissara
Thanusak Tatu
Torpong Sanguansermsri
Gonzague Jourdoin
Marc Lallemant
Sophie Le Coeur
author_sort Nelly Briand
title Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
title_short Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
title_full Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
title_fullStr Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
title_full_unstemmed Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand
title_sort perinatal zidovudine prophylaxis in hiv type-1-infected pregnant women with thalassaemia carriage in thailand
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=61849158733&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49365
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