Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity
Patients with thalassemia major have inevitably suffered from complications of the disease, due to iron overload. Among such complications, cardiomyopathy is the leading cause of morbidity and mortality (63.6% to 71%). The major causes of death in this group of patients are congestive heart failure...
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th-cmuir.6653943832-493892018-08-16T02:15:45Z Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity Suree Lekawanvijit Nipon Chattipakorn Medicine Patients with thalassemia major have inevitably suffered from complications of the disease, due to iron overload. Among such complications, cardiomyopathy is the leading cause of morbidity and mortality (63.6% to 71%). The major causes of death in this group of patients are congestive heart failure and fatal cardiac tachyarrhythmias leading to sudden cardiac death. The free radical-mediated pathway is the principal mechanism of iron toxicity. The consequent series of events caused by iron overload lead to catastrophic cardiac effects. The authors review the electrophysiological and molecular mechanisms, pathophysiology and correlated clinical insight of heart failure and arrhythmias in iron overload thalassemic cardiomyopathy. © 2009 Pulsus Group Inc. All rights reserved. 2018-08-16T02:15:45Z 2018-08-16T02:15:45Z 2009-01-01 Journal 0828282X 2-s2.0-65349175614 10.1016/S0828-282X(09)70064-9 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65349175614&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49389 |
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Medicine Suree Lekawanvijit Nipon Chattipakorn Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| description |
Patients with thalassemia major have inevitably suffered from complications of the disease, due to iron overload. Among such complications, cardiomyopathy is the leading cause of morbidity and mortality (63.6% to 71%). The major causes of death in this group of patients are congestive heart failure and fatal cardiac tachyarrhythmias leading to sudden cardiac death. The free radical-mediated pathway is the principal mechanism of iron toxicity. The consequent series of events caused by iron overload lead to catastrophic cardiac effects. The authors review the electrophysiological and molecular mechanisms, pathophysiology and correlated clinical insight of heart failure and arrhythmias in iron overload thalassemic cardiomyopathy. © 2009 Pulsus Group Inc. All rights reserved. |
| format |
Journal |
| author |
Suree Lekawanvijit Nipon Chattipakorn |
| author_facet |
Suree Lekawanvijit Nipon Chattipakorn |
| author_sort |
Suree Lekawanvijit |
| title |
Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| title_short |
Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| title_full |
Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| title_fullStr |
Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| title_full_unstemmed |
Iron overload thalassemic cardiomyopathy: Iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| title_sort |
iron overload thalassemic cardiomyopathy: iron status assessment and mechanisms of mechanical and electrical disturbance due to iron toxicity |
| publishDate |
2018 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=65349175614&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49389 |
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