Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum

From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spect...

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Main Authors: Suksamrarn A., Buaprom M., Udtip S., Nuntawong N., Haritakun R., Kanokmedhakul S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-26444447960&partnerID=40&md5=30f0125fb91594aa81a88d5d61791e0c
http://cmuir.cmu.ac.th/handle/6653943832/4939
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-49392014-08-30T02:55:58Z Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum Suksamrarn A. Buaprom M. Udtip S. Nuntawong N. Haritakun R. Kanokmedhakul S. From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC50 value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays. © 2005 Pharmaceutical Society of Japan. 2014-08-30T02:55:58Z 2014-08-30T02:55:58Z 2005 Article 00092363 10.1248/cpb.53.1327 16204994 CPBTA http://www.scopus.com/inward/record.url?eid=2-s2.0-26444447960&partnerID=40&md5=30f0125fb91594aa81a88d5d61791e0c http://cmuir.cmu.ac.th/handle/6653943832/4939 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description From the twigs of Scleropyrum wallichianum, a new unsaturated carboxylic acid, scleropyric acid (1), two new esters, β-sitosteryl-3-O-scleropyrate (2) and stigmasteryl-3-O-scleropyrate (3), and two well-known sterols, β-sitosterol (4) and stigmasterol (5), were isolated and characterized using spectroscopic methods. Compound 1 exhibited antimycobacterial activity with an MIC value of 25 μg/ml and showed antiplasmodial activity with an IC50 value of 7.2 μg/ml. Compounds 2 and 3 were inactive in both assays. © 2005 Pharmaceutical Society of Japan.
format Article
author Suksamrarn A.
Buaprom M.
Udtip S.
Nuntawong N.
Haritakun R.
Kanokmedhakul S.
spellingShingle Suksamrarn A.
Buaprom M.
Udtip S.
Nuntawong N.
Haritakun R.
Kanokmedhakul S.
Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
author_facet Suksamrarn A.
Buaprom M.
Udtip S.
Nuntawong N.
Haritakun R.
Kanokmedhakul S.
author_sort Suksamrarn A.
title Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_short Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_full Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_fullStr Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_full_unstemmed Antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of Scleropyrum wallichianum
title_sort antimycobacterial and antiplasmodial unsaturated carboxylic acid from the twigs of scleropyrum wallichianum
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-26444447960&partnerID=40&md5=30f0125fb91594aa81a88d5d61791e0c
http://cmuir.cmu.ac.th/handle/6653943832/4939
_version_ 1681420331367006208

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