Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait

Objective: To evaluate sensitivity, specificity, and positive and negative predictive value of mean corpuscular hemoglobin (MCH) for screening alpha-thalassemia-1 trait and beta-thalassemia trait Material and Method: Descriptive analysis, diagnostic test, was conducted on 396 pregnant women attendin...

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Main Authors: Savitree Pranpanus, Supatra Sirichotiyakul, Kasemsri Srisupundit, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49392
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-493922018-08-16T02:15:46Z Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait Savitree Pranpanus Supatra Sirichotiyakul Kasemsri Srisupundit Theera Tongsong Medicine Objective: To evaluate sensitivity, specificity, and positive and negative predictive value of mean corpuscular hemoglobin (MCH) for screening alpha-thalassemia-1 trait and beta-thalassemia trait Material and Method: Descriptive analysis, diagnostic test, was conducted on 396 pregnant women attending the antenatal clinic between September 2007 and June 2008. Blood samples were collected from pregnant women after counseling and getting informed consent. MCH was measured in all samples by automated hematology analyzer. Determination of HbA2 level for diagnosis of beta-thalassmia trait and PCR for alphat-halassemia-1 gene (SEA type) were performed in all cases as a gold standard. The data were collected and analyzed for sensitivity, specificity, and positive and negative predictive value of MCH for screening alpha-thalassemia-1 trait and beta-thalassemia trait. Results: Based on the ROC curve, the best cut-off level of MCH in predicting the thalassemia carriers was 26.5 picrograms. Positive MCH (< 26.5 picrograms) gave the sensitivity of 95.2% and specificity of 82.3% in screening alpha-thalassemia-1 trait and beta-thalassemia trait. The positive predictive value and negative predictive value were 40.4% and 99.3% respectively. Conclusion: MCH is a good tool for screening alpha-thalassemia-1 trait and beta-thalassemia trait during pregnancy because of its simplicity, low cost, (when determined as a part of complete blood count), and high sensitivity. 2018-08-16T02:15:46Z 2018-08-16T02:15:46Z 2009-01-01 Journal 01252208 01252208 2-s2.0-67650450528 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650450528&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49392
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Savitree Pranpanus
Supatra Sirichotiyakul
Kasemsri Srisupundit
Theera Tongsong
Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
description Objective: To evaluate sensitivity, specificity, and positive and negative predictive value of mean corpuscular hemoglobin (MCH) for screening alpha-thalassemia-1 trait and beta-thalassemia trait Material and Method: Descriptive analysis, diagnostic test, was conducted on 396 pregnant women attending the antenatal clinic between September 2007 and June 2008. Blood samples were collected from pregnant women after counseling and getting informed consent. MCH was measured in all samples by automated hematology analyzer. Determination of HbA2 level for diagnosis of beta-thalassmia trait and PCR for alphat-halassemia-1 gene (SEA type) were performed in all cases as a gold standard. The data were collected and analyzed for sensitivity, specificity, and positive and negative predictive value of MCH for screening alpha-thalassemia-1 trait and beta-thalassemia trait. Results: Based on the ROC curve, the best cut-off level of MCH in predicting the thalassemia carriers was 26.5 picrograms. Positive MCH (< 26.5 picrograms) gave the sensitivity of 95.2% and specificity of 82.3% in screening alpha-thalassemia-1 trait and beta-thalassemia trait. The positive predictive value and negative predictive value were 40.4% and 99.3% respectively. Conclusion: MCH is a good tool for screening alpha-thalassemia-1 trait and beta-thalassemia trait during pregnancy because of its simplicity, low cost, (when determined as a part of complete blood count), and high sensitivity.
format Journal
author Savitree Pranpanus
Supatra Sirichotiyakul
Kasemsri Srisupundit
Theera Tongsong
author_facet Savitree Pranpanus
Supatra Sirichotiyakul
Kasemsri Srisupundit
Theera Tongsong
author_sort Savitree Pranpanus
title Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
title_short Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
title_full Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
title_fullStr Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
title_full_unstemmed Sensitivity and specificity of mean corpuscular hemoglobin (MCH): For screening alpha-thalassemia-1 trait and beta-thalassemia trait
title_sort sensitivity and specificity of mean corpuscular hemoglobin (mch): for screening alpha-thalassemia-1 trait and beta-thalassemia trait
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=67650450528&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49392
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