Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture

This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-C...

Full description

Saved in:
Bibliographic Details
Main Authors: Baimark Y., Molloy R., Molloy N., Siripitayananon J., Punyodom W., Sriyai M.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-21344448165&partnerID=40&md5=a3ff1b64ba4e45b62ab7cdf5ac95ca71
http://cmuir.cmu.ac.th/handle/6653943832/4963
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-4963
record_format dspace
spelling th-cmuir.6653943832-49632014-08-30T02:56:00Z Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture Baimark Y. Molloy R. Molloy N. Siripitayananon J. Punyodom W. Sriyai M. This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-CL), was synthesized via bulk copolymerization of LL and CL. This first-step prepolymer then became the macroinitiator in the second-step reaction in which more LL monomer was added to form a block copolymer, PLL-b-P(LL-co-CL)-b-PLL. Both the prepolymer and block copolymer were characterized by a combination of analytical techniques comprising dilute-solution viscometry, GPC, 1H and 13C NMR, DSC and TG. The block copolymer was then processed into a monofilament fiber using a small-scale melt spinning apparatus. The fiber was spun with a minimum amount of chain orientation and crystallinity so that its semi-crystalline morphology could be constructed under more controlled conditions in subsequent off-line hot-drawing and annealing steps. In this way, the fiber's tensile properties and dimensional stability were developed, as indicated by the changes in its stress-strain curve. The final drawn and annealed fiber had a tensile strength (> 400 MPa) approaching that of a commercial PDS II suture of similar size. It is considered that this type of block copolymer has the potential to be developed further as a lower-cost alternative to the current commercial monofilament surgical sutures. © 2005 Springer Science + Business Media, Inc. 2014-08-30T02:56:00Z 2014-08-30T02:56:00Z 2005 Article 09574530 10.1007/s10856-005-2605-6 15965738 JSMME http://www.scopus.com/inward/record.url?eid=2-s2.0-21344448165&partnerID=40&md5=a3ff1b64ba4e45b62ab7cdf5ac95ca71 http://cmuir.cmu.ac.th/handle/6653943832/4963 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description This paper describes the synthesis and characterization of a block copolymer of L-lactide (LL) and ε-caprolactone (CL) and its subsequent melt spinning into a monofilament fiber. The synthesis reaction was a two-step process. In the first step, an approximately 50:50 mol% random copolymer, P(LL-co-CL), was synthesized via bulk copolymerization of LL and CL. This first-step prepolymer then became the macroinitiator in the second-step reaction in which more LL monomer was added to form a block copolymer, PLL-b-P(LL-co-CL)-b-PLL. Both the prepolymer and block copolymer were characterized by a combination of analytical techniques comprising dilute-solution viscometry, GPC, 1H and 13C NMR, DSC and TG. The block copolymer was then processed into a monofilament fiber using a small-scale melt spinning apparatus. The fiber was spun with a minimum amount of chain orientation and crystallinity so that its semi-crystalline morphology could be constructed under more controlled conditions in subsequent off-line hot-drawing and annealing steps. In this way, the fiber's tensile properties and dimensional stability were developed, as indicated by the changes in its stress-strain curve. The final drawn and annealed fiber had a tensile strength (> 400 MPa) approaching that of a commercial PDS II suture of similar size. It is considered that this type of block copolymer has the potential to be developed further as a lower-cost alternative to the current commercial monofilament surgical sutures. © 2005 Springer Science + Business Media, Inc.
format Article
author Baimark Y.
Molloy R.
Molloy N.
Siripitayananon J.
Punyodom W.
Sriyai M.
spellingShingle Baimark Y.
Molloy R.
Molloy N.
Siripitayananon J.
Punyodom W.
Sriyai M.
Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
author_facet Baimark Y.
Molloy R.
Molloy N.
Siripitayananon J.
Punyodom W.
Sriyai M.
author_sort Baimark Y.
title Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_short Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_full Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_fullStr Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_full_unstemmed Synthesis, characterization and melt spinning of a block copolymer of L-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
title_sort synthesis, characterization and melt spinning of a block copolymer of l-lactide and ε-caprolactone for potential use as an absorbable monofilament surgical suture
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-21344448165&partnerID=40&md5=a3ff1b64ba4e45b62ab7cdf5ac95ca71
http://cmuir.cmu.ac.th/handle/6653943832/4963
_version_ 1681420335799336960