Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines

• Main Authors: Benjawan Wudtiwai, Bungorn Sripanidkulchai, Prachya Kongtawelert, Ratana Banjerdpongchai
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=83755173700&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49656
• Institution: Chiang Mai University

Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells, but does not affect normal cells or human leukemic cells, such as MOLT-4 and U937 cells, which are relatively resistant to TRAIL. Three flavonoids extracted from the rhizome of K. pa...