Induction of G1 arrest and apoptosis in androgen-dependent human prostate cancer by Kuguacin J, a triterpenoid from Momordica charantia leaf

• Main Authors: Pornsiri Pitchakarn, Shugo Suzuki, Kumiko Ogawa, Wilart Pompimon, Satoru Takahashi, Makoto Asamoto, Pornngarm Limtrakul, Tomoyuki Shirai
• 格式: 雜誌
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Medicine
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955465233&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49700
• 機構: Chiang Mai University

In this study, we focused on the effects of a bitter melon (Momordica charantia) leaf extract (BMLE) and a purified component, Kuguacin J (KuJ), on androgen-dependent LNCaP human prostate cancer cells. Both treatments exerted growth inhibition through G1 arrest and induction of apoptosis. In additio...