The association of hormonal contraceptive use and HPV prevalence

Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to...

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Main Authors: Morgan Marks, Patti E. Gravitt, Swati B. Gupta, Kai Li Liaw, Esther Kim, Amha Tadesse, Chailert Phongnarisorn, Virach Wootipoom, Pissamai Yuenyao, Charoen Vipupinyo, Sungwal Rugpao, Somchai Sriplienchan, David D. Celentano
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Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49708
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-497082018-09-04T04:26:36Z The association of hormonal contraceptive use and HPV prevalence Morgan Marks Patti E. Gravitt Swati B. Gupta Kai Li Liaw Esther Kim Amha Tadesse Chailert Phongnarisorn Virach Wootipoom Pissamai Yuenyao Charoen Vipupinyo Sungwal Rugpao Somchai Sriplienchan David D. Celentano Biochemistry, Genetics and Molecular Biology Medicine Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the association of contraceptive use on the risk for prevalent HPV infection in a cohort of long-term hormonal contraceptive (HC) users. One thousand and seventy (n = 1,070) HIV-negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. Baseline HPV genotype information, recency and duration of HC use, sexual behavior, other sexually transmitted infection (STI) information and cervical cytology and histology were assessed. At enrollment, 19.8% and 11.5% of women were infected with any HPV or any high-risk (HR)-HPV, respectively. After adjustment for age, current and past sexual risk behaviors, STI history and cytology, the use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV [prevalence ratio (PR): 1.88 (1.21, 2.90)] and any HR-HPV [PR: 2.68 (1.47, 4.88)] as compared to never users. Recent, long-term COC use was associated with an increased risk for prevalent HPV infection independent of sexual behavior and cervical abnormalities. No similar association was observed for recent or long duration use of progestin-only contraceptives (i.e., depomedroxyprogesterone acetate). These data suggest that COC use may impact early upstream events in the natural history of HPV infection. © 2010 UICC. 2018-09-04T04:05:49Z 2018-09-04T04:05:49Z 2011-06-15 Journal 10970215 00207136 2-s2.0-79955392446 10.1002/ijc.25628 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955392446&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49708
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Medicine
spellingShingle Biochemistry, Genetics and Molecular Biology
Medicine
Morgan Marks
Patti E. Gravitt
Swati B. Gupta
Kai Li Liaw
Esther Kim
Amha Tadesse
Chailert Phongnarisorn
Virach Wootipoom
Pissamai Yuenyao
Charoen Vipupinyo
Sungwal Rugpao
Somchai Sriplienchan
David D. Celentano
The association of hormonal contraceptive use and HPV prevalence
description Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the association of contraceptive use on the risk for prevalent HPV infection in a cohort of long-term hormonal contraceptive (HC) users. One thousand and seventy (n = 1,070) HIV-negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. Baseline HPV genotype information, recency and duration of HC use, sexual behavior, other sexually transmitted infection (STI) information and cervical cytology and histology were assessed. At enrollment, 19.8% and 11.5% of women were infected with any HPV or any high-risk (HR)-HPV, respectively. After adjustment for age, current and past sexual risk behaviors, STI history and cytology, the use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV [prevalence ratio (PR): 1.88 (1.21, 2.90)] and any HR-HPV [PR: 2.68 (1.47, 4.88)] as compared to never users. Recent, long-term COC use was associated with an increased risk for prevalent HPV infection independent of sexual behavior and cervical abnormalities. No similar association was observed for recent or long duration use of progestin-only contraceptives (i.e., depomedroxyprogesterone acetate). These data suggest that COC use may impact early upstream events in the natural history of HPV infection. © 2010 UICC.
format Journal
author Morgan Marks
Patti E. Gravitt
Swati B. Gupta
Kai Li Liaw
Esther Kim
Amha Tadesse
Chailert Phongnarisorn
Virach Wootipoom
Pissamai Yuenyao
Charoen Vipupinyo
Sungwal Rugpao
Somchai Sriplienchan
David D. Celentano
author_facet Morgan Marks
Patti E. Gravitt
Swati B. Gupta
Kai Li Liaw
Esther Kim
Amha Tadesse
Chailert Phongnarisorn
Virach Wootipoom
Pissamai Yuenyao
Charoen Vipupinyo
Sungwal Rugpao
Somchai Sriplienchan
David D. Celentano
author_sort Morgan Marks
title The association of hormonal contraceptive use and HPV prevalence
title_short The association of hormonal contraceptive use and HPV prevalence
title_full The association of hormonal contraceptive use and HPV prevalence
title_fullStr The association of hormonal contraceptive use and HPV prevalence
title_full_unstemmed The association of hormonal contraceptive use and HPV prevalence
title_sort association of hormonal contraceptive use and hpv prevalence
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955392446&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49708
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