Glycoproteomic analysis and molecular modeling of haptoglobin multimers

• Main Authors: Kongsak Boonyapranai, Hsien Yu Tsai, Miles Chih Ming Chen, Supawadee Sriyam, Supachok Sinchaikul, Suree Phutrakul, Shui Tien Chen
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79959400820&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49711
• Institution: Chiang Mai University

Extra-thiol groups on the α-subunit allow haptoglobin (Hp) to form a variety of native multimers which influence the biophysical and biological properties of Hp. In this work, we demonstrated how differences of multimeric conformation alter the glycosylation of Hp. The isoform distributions of diffe...