Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer

Glycosylation is a common protein modification that is of interest in current cancer research because altered carbohydrate moieties are often found during cancer progress. A search for biomarkers in human lung cancer serum samples using glycoproteomic approaches identified fucosylated haptoglobin (H...

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Main Authors: Hsien Yu Tsai, Kongsak Boonyapranai, Supawadee Sriyam, Chong Jen Yu, Sz Wei Wu, Kay Hooi Khoo, Suree Phutrakul, Shui Tein Chen
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49716
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-497162018-09-04T04:05:53Z Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer Hsien Yu Tsai Kongsak Boonyapranai Supawadee Sriyam Chong Jen Yu Sz Wei Wu Kay Hooi Khoo Suree Phutrakul Shui Tein Chen Biochemistry, Genetics and Molecular Biology Glycosylation is a common protein modification that is of interest in current cancer research because altered carbohydrate moieties are often found during cancer progress. A search for biomarkers in human lung cancer serum samples using glycoproteomic approaches identified fucosylated haptoglobin (Hp) significantly increased in serum of each subtype of lung cancer compared to normal donors. In addition, MS provided evidence of an increase of Hp fucosylation; the glycan structure was determined to be an α 2,6-linked tri-sialylated triantennary glycan containing α1,3-linked fucose attached to the four-linked position of the three-arm mannose of N-linked core pentasaccharide. These preliminary findings suggest that the specific glycoform of Hp may be useful as a marker to monitor lung cancer progression. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. 2018-09-04T04:05:53Z 2018-09-04T04:05:53Z 2011-06-01 Journal 16159861 16159853 2-s2.0-79956282745 10.1002/pmic.201000319 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956282745&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49716
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
spellingShingle Biochemistry, Genetics and Molecular Biology
Hsien Yu Tsai
Kongsak Boonyapranai
Supawadee Sriyam
Chong Jen Yu
Sz Wei Wu
Kay Hooi Khoo
Suree Phutrakul
Shui Tein Chen
Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
description Glycosylation is a common protein modification that is of interest in current cancer research because altered carbohydrate moieties are often found during cancer progress. A search for biomarkers in human lung cancer serum samples using glycoproteomic approaches identified fucosylated haptoglobin (Hp) significantly increased in serum of each subtype of lung cancer compared to normal donors. In addition, MS provided evidence of an increase of Hp fucosylation; the glycan structure was determined to be an α 2,6-linked tri-sialylated triantennary glycan containing α1,3-linked fucose attached to the four-linked position of the three-arm mannose of N-linked core pentasaccharide. These preliminary findings suggest that the specific glycoform of Hp may be useful as a marker to monitor lung cancer progression. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
format Journal
author Hsien Yu Tsai
Kongsak Boonyapranai
Supawadee Sriyam
Chong Jen Yu
Sz Wei Wu
Kay Hooi Khoo
Suree Phutrakul
Shui Tein Chen
author_facet Hsien Yu Tsai
Kongsak Boonyapranai
Supawadee Sriyam
Chong Jen Yu
Sz Wei Wu
Kay Hooi Khoo
Suree Phutrakul
Shui Tein Chen
author_sort Hsien Yu Tsai
title Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
title_short Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
title_full Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
title_fullStr Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
title_full_unstemmed Glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
title_sort glycoproteomics analysis to identify a glycoform on haptoglobin associated with lung cancer
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79956282745&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49716
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