Biotransformation of natural compounds. Oxido-reduction of Sch-642305 by Aspergillus ochraceus ATCC 1009

• Main Authors: Emilie Adelin, Claudine Servy, Sylvie Cortial, Hélne Lévaique, Jean Franois Gallard, Marie Thérse Martin, Pascal Retailleau, Boonsom Bussaban, Saisamorn Lumyong, Jamal Ouazzani
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79953278003&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49726
• Institution: Chiang Mai University

Sch-642305 is the major compound produced by the endophytic fungi Phomopsis sp. CMU-LMA. Incubation of Sch-642305 with Aspergillus ochraceus ATCC 1009 resting cells leads to three new derivatives through an oxido-reduction of the six-membered ring of the molecule. Reduction of the double bound leads...