Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans

A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts...

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Main Authors: Thanapat Sastraruji, Sukanda Chaiyong, Araya Jatisatienr, Stephen G. Pyne, Alison T. Ung, Wilford Lie
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/49744
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-497442018-09-04T04:29:08Z Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans Thanapat Sastraruji Sukanda Chaiyong Araya Jatisatienr Stephen G. Pyne Alison T. Ung Wilford Lie Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active than 1',2'-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities. Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL. © 2011 American Chemical Society and American Society of Pharmacognosy. 2018-09-04T04:17:31Z 2018-09-04T04:17:31Z 2011-01-28 Journal 15206025 01633864 2-s2.0-79951545662 10.1021/np100668s https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951545662&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49744
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Thanapat Sastraruji
Sukanda Chaiyong
Araya Jatisatienr
Stephen G. Pyne
Alison T. Ung
Wilford Lie
Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
description A new stemofoline alkaloid, (2'S)-hydroxy-(11S,12R)-dihydrostemofoline (3), new stemofurans M-R (8-13), and known compounds stemofoline (1), (2'S)-hydroxystemofoline (2), stemofuran E (4), stemofuran F (5), stemofuran J (6), and stilbostemin F (7) have been isolated from the root extracts of Stemona aphylla. The structures and relative configurations of these new compounds have been determined by spectroscopic data interpretation and from semisynthetic studies. These natural and semisynthetic alkaloids were tested for acetylcholinesterase inhibitory activities and were found to be 10-20 times less active than 1',2'-didehydrostemofoline itself. Stemofurans 4, 6, 8, 11, and 13 were tested for their antibacterial and antifungal activities. Three of these showed antibacterial activities against MRSA with MIC values of 15.6 μg/mL. © 2011 American Chemical Society and American Society of Pharmacognosy.
format Journal
author Thanapat Sastraruji
Sukanda Chaiyong
Araya Jatisatienr
Stephen G. Pyne
Alison T. Ung
Wilford Lie
author_facet Thanapat Sastraruji
Sukanda Chaiyong
Araya Jatisatienr
Stephen G. Pyne
Alison T. Ung
Wilford Lie
author_sort Thanapat Sastraruji
title Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
title_short Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
title_full Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
title_fullStr Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
title_full_unstemmed Phytochemical studies on Stemona aphylla: Isolation of a new stemofoline alkaloid and six new stemofurans
title_sort phytochemical studies on stemona aphylla: isolation of a new stemofoline alkaloid and six new stemofurans
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951545662&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49744
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