Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum
The cardiovascular effects of the water extract from fresh leaves of P. palatiferum (PP) were evaluated in rats in both in vivo and in vitro models. The PP extract consisted of alkaloids, coumarins and sterols. The extract (5-25 mg/kg, I.V.) decreased both the mean arterial blood pressure and heart...
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th-cmuir.6653943832-498192018-09-04T04:28:53Z Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum Parirat Khonsung A. Panthong N. Chiranthanut S. Intahphuak Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics The cardiovascular effects of the water extract from fresh leaves of P. palatiferum (PP) were evaluated in rats in both in vivo and in vitro models. The PP extract consisted of alkaloids, coumarins and sterols. The extract (5-25 mg/kg, I.V.) decreased both the mean arterial blood pressure and heart rate of normotensive and l-N-(ω)-nitro-arginine methyl ester (l-NAME)-induced hypertensive anesthetized rats. The extract caused relaxation of the norepinephrine-contracted endothelium-intact aorta ring (EC50= 81.0 μg/mL). Functional removal of the endothelium attenuated the vasodilatation effect of the extract (EC50= 136.4 μg/mL). Pretreatment with l-NAME or atropine did not alter the vasodilation effect of the extract. Pre-incubation with atropine did not alter bradycardic effect of the extract on isolated rat atrium. The effects of isoproterenol on isolated atrium were attenuated by the extract (2.5-5 mg/mL). In conclusion, the water extract from fresh leaves of P. palatiferum possessed hypotensive and bradycardic effects. The vasorelaxant effect of the extract was dependent partly on the vascular endothelium but was not dependent on the synthesis of nitric oxide and did not act through activation of the muscarinic receptor. © 2011 The Japanese Society of Pharmacognosy and Springer. 2018-09-04T04:18:41Z 2018-09-04T04:18:41Z 2011-07-01 Journal 18610293 13403443 2-s2.0-79960444534 10.1007/s11418-011-0540-z https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960444534&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49819 |
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Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Parirat Khonsung A. Panthong N. Chiranthanut S. Intahphuak Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
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The cardiovascular effects of the water extract from fresh leaves of P. palatiferum (PP) were evaluated in rats in both in vivo and in vitro models. The PP extract consisted of alkaloids, coumarins and sterols. The extract (5-25 mg/kg, I.V.) decreased both the mean arterial blood pressure and heart rate of normotensive and l-N-(ω)-nitro-arginine methyl ester (l-NAME)-induced hypertensive anesthetized rats. The extract caused relaxation of the norepinephrine-contracted endothelium-intact aorta ring (EC50= 81.0 μg/mL). Functional removal of the endothelium attenuated the vasodilatation effect of the extract (EC50= 136.4 μg/mL). Pretreatment with l-NAME or atropine did not alter the vasodilation effect of the extract. Pre-incubation with atropine did not alter bradycardic effect of the extract on isolated rat atrium. The effects of isoproterenol on isolated atrium were attenuated by the extract (2.5-5 mg/mL). In conclusion, the water extract from fresh leaves of P. palatiferum possessed hypotensive and bradycardic effects. The vasorelaxant effect of the extract was dependent partly on the vascular endothelium but was not dependent on the synthesis of nitric oxide and did not act through activation of the muscarinic receptor. © 2011 The Japanese Society of Pharmacognosy and Springer. |
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Parirat Khonsung A. Panthong N. Chiranthanut S. Intahphuak |
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Parirat Khonsung A. Panthong N. Chiranthanut S. Intahphuak |
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Parirat Khonsung |
title |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
title_short |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
title_full |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
title_fullStr |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
title_full_unstemmed |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum |
title_sort |
hypotensive effect of the water extract of the leaves of pseuderanthemum palatiferum |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79960444534&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49819 |
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