Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant

A sequential injection analysis (SIA) spectrophotometric method for determining tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) in different sample matrices were described. The method was based on the reaction between tetracyclines and yttrium (III) in weak basic micellar medium...

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Main Authors: Wish Thanasarakhan, Senee Kruanetr, Richard L. Deming, Boonsom Liawruangrath, Sunantha Wangkarn, Saisunee Liawruangrath
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Published: 2018
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spelling th-cmuir.6653943832-498272018-09-04T04:18:45Z Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant Wish Thanasarakhan Senee Kruanetr Richard L. Deming Boonsom Liawruangrath Sunantha Wangkarn Saisunee Liawruangrath Chemistry A sequential injection analysis (SIA) spectrophotometric method for determining tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) in different sample matrices were described. The method was based on the reaction between tetracyclines and yttrium (III) in weak basic micellar medium, yielding the light yellow complexes, which were monitored at 390, 392 and 395 nm, respectively. A cationic surfactant, cetyltrimethylammonium bromide (CTAB) was used to obtain the micellar system. The linear ranges of calibration graphs were between 1.0 × 10-5and 4 × 10-4mol L-1, respectively. The molar absorptivities were 5.24 × 105, 4.98 × 104and 4.78 × 104L mol-1cm-1. The detection limits (3σ) were between 4.9 × 10-6and 7.8 × 10-6mol L-1whereas the limit of quantitations (10σ) were between 1.63 × 10-5and 2.60 × 10-5mol L-1the interday and intraday precisions within a weak revealed as the relative standard deviations (R.S.D., n = 11) were less than 4%. The method was rapid with a sampling rate of over 60 samples h-1for the three drugs. The proposed method has been satisfactorily applied for the determination of tetracycline and its derivatives in pharmaceutical preparations together with their residues in milk and honey samples collected in Chiang Mai Province. The accuracy was found to be high as the Student's t-values were found to be less than the theoretical ones. The results were compared favorably with those obtained by the conventional spectrophotometric method. © 2011 Elsevier B.V. All rights reserved. 2018-09-04T04:18:45Z 2018-09-04T04:18:45Z 2011-06-15 Journal 00399140 2-s2.0-79958098006 10.1016/j.talanta.2011.03.087 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79958098006&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/49827
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Chemistry
spellingShingle Chemistry
Wish Thanasarakhan
Senee Kruanetr
Richard L. Deming
Boonsom Liawruangrath
Sunantha Wangkarn
Saisunee Liawruangrath
Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
description A sequential injection analysis (SIA) spectrophotometric method for determining tetracycline (TC), chlortetracycline (CTC) and oxytetracycline (OTC) in different sample matrices were described. The method was based on the reaction between tetracyclines and yttrium (III) in weak basic micellar medium, yielding the light yellow complexes, which were monitored at 390, 392 and 395 nm, respectively. A cationic surfactant, cetyltrimethylammonium bromide (CTAB) was used to obtain the micellar system. The linear ranges of calibration graphs were between 1.0 × 10-5and 4 × 10-4mol L-1, respectively. The molar absorptivities were 5.24 × 105, 4.98 × 104and 4.78 × 104L mol-1cm-1. The detection limits (3σ) were between 4.9 × 10-6and 7.8 × 10-6mol L-1whereas the limit of quantitations (10σ) were between 1.63 × 10-5and 2.60 × 10-5mol L-1the interday and intraday precisions within a weak revealed as the relative standard deviations (R.S.D., n = 11) were less than 4%. The method was rapid with a sampling rate of over 60 samples h-1for the three drugs. The proposed method has been satisfactorily applied for the determination of tetracycline and its derivatives in pharmaceutical preparations together with their residues in milk and honey samples collected in Chiang Mai Province. The accuracy was found to be high as the Student's t-values were found to be less than the theoretical ones. The results were compared favorably with those obtained by the conventional spectrophotometric method. © 2011 Elsevier B.V. All rights reserved.
format Journal
author Wish Thanasarakhan
Senee Kruanetr
Richard L. Deming
Boonsom Liawruangrath
Sunantha Wangkarn
Saisunee Liawruangrath
author_facet Wish Thanasarakhan
Senee Kruanetr
Richard L. Deming
Boonsom Liawruangrath
Sunantha Wangkarn
Saisunee Liawruangrath
author_sort Wish Thanasarakhan
title Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
title_short Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
title_full Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
title_fullStr Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
title_full_unstemmed Sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (III) and cationic surfactant
title_sort sequential injection spectrophotometric determination of tetracycline antibiotics in pharmaceutical preparations and their residues in honey and milk samples using yttrium (iii) and cationic surfactant
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79958098006&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/49827
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