3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line

• Main Authors: Takashi Kikuchi, Hiroyuki Akazawa, Keiichi Tabata, Aranya Manosroi, Jiradej Manosroi, Takashi Suzuki, Toshihiro Akihisa
• Format: Journal
• Published: 2018
• Subjects: Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79952412542&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/49844
• Institution: Chiang Mai University

Eleven triterpene acids, 1-11, isolated from the leaves of Eriobotrya japonica, were evaluated for inhibition of DNA topoisomerase (Topo) I and cytotoxicity against human leukemia (HL60) and melanoma cell lines (CRL1579). Among the compounds tested, four compounds, d-oleanolic acid (4), ursolic acid...