Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug

Objective: To determine hypotensive effect of nifedipine in the treatment of preterm labor. Methods: A descriptive analytic study was conducted on pregnant women treated with nifedipine as tocolytic drug for preterm labor. Maternal blood pressure before and at 15, 30, 45 and 60 min after administrat...

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Main Authors: Suchaya Luewan, Rathasart Mahathep, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50178
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-501782018-09-04T04:26:04Z Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug Suchaya Luewan Rathasart Mahathep Theera Tongsong Medicine Objective: To determine hypotensive effect of nifedipine in the treatment of preterm labor. Methods: A descriptive analytic study was conducted on pregnant women treated with nifedipine as tocolytic drug for preterm labor. Maternal blood pressure before and at 15, 30, 45 and 60 min after administration of nifedipine was evaluated and analyzed. Hypotension was defined as a decrease in systolic or diastolic blood pressure of 15 mmHg or more. Results: A total of 157 pregnant women met the inclusion criteria. The mean systolic and diastolic blood pressure before treatment was 109.4 and 72.5 mmHg, respectively. The blood pressure following treatment with nifedipine was significantly decreased both systolic and diastolic blood pressure (p < 0.05) at 30, 45 and 60 min. Of 157 patients, 28 (17.8%) and 27 (17.2%) had systolic and diastolic hypotension, respectively. Of the patients with decreased blood pressure, the mean decrease of systolic and diastolic blood pressure was 16.3 and 14.5 mmHg, respectively. Conclusion: Nifedipine was associated with a minimal but significant decrease in blood pressure. 17% of cases have hypotension. However, hypotension secondary to nifedipine was not associated with significant clinical symptoms, suggesting that nifedipine is relatively safe in terms of hypotensive effect. © Springer-Verlag 2010. 2018-09-04T04:26:04Z 2018-09-04T04:26:04Z 2011-09-01 Journal 14320711 09320067 2-s2.0-84856011258 10.1007/s00404-010-1674-z https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856011258&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50178
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Suchaya Luewan
Rathasart Mahathep
Theera Tongsong
Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
description Objective: To determine hypotensive effect of nifedipine in the treatment of preterm labor. Methods: A descriptive analytic study was conducted on pregnant women treated with nifedipine as tocolytic drug for preterm labor. Maternal blood pressure before and at 15, 30, 45 and 60 min after administration of nifedipine was evaluated and analyzed. Hypotension was defined as a decrease in systolic or diastolic blood pressure of 15 mmHg or more. Results: A total of 157 pregnant women met the inclusion criteria. The mean systolic and diastolic blood pressure before treatment was 109.4 and 72.5 mmHg, respectively. The blood pressure following treatment with nifedipine was significantly decreased both systolic and diastolic blood pressure (p < 0.05) at 30, 45 and 60 min. Of 157 patients, 28 (17.8%) and 27 (17.2%) had systolic and diastolic hypotension, respectively. Of the patients with decreased blood pressure, the mean decrease of systolic and diastolic blood pressure was 16.3 and 14.5 mmHg, respectively. Conclusion: Nifedipine was associated with a minimal but significant decrease in blood pressure. 17% of cases have hypotension. However, hypotension secondary to nifedipine was not associated with significant clinical symptoms, suggesting that nifedipine is relatively safe in terms of hypotensive effect. © Springer-Verlag 2010.
format Journal
author Suchaya Luewan
Rathasart Mahathep
Theera Tongsong
author_facet Suchaya Luewan
Rathasart Mahathep
Theera Tongsong
author_sort Suchaya Luewan
title Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
title_short Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
title_full Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
title_fullStr Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
title_full_unstemmed Hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
title_sort hypotension in normotensive pregnant women treated with nifedipine as a tocolytic drug
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856011258&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50178
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