Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?

Objective: To compare the efficacy and adverse effects of 400 μg intravaginal misoprostol for second-trimester pregnancy termination in live fetuses between two groups: one in which misoprostol was moistened with normal saline solution (NSS) and the other in which misoprostol was moistened with acet...

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Main Authors: Saipin Pongsatha, Theera Tongsong
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50205
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-502052018-09-04T04:26:29Z Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different? Saipin Pongsatha Theera Tongsong Medicine Objective: To compare the efficacy and adverse effects of 400 μg intravaginal misoprostol for second-trimester pregnancy termination in live fetuses between two groups: one in which misoprostol was moistened with normal saline solution (NSS) and the other in which misoprostol was moistened with acetic acid. Materials and Methods: A total of 179 pregnant women between 14 and 28 weeks of gestation with live fetuses indicated for pregnancy termination were recruited. They were randomly allocated to receive 400 μg intravaginal misoprostol either moistened with NSS (n = 96) or moistened with acetic acid (n = 83). The same dosage was then repeated every 3 h if adequate uterine contractions were not achieved until 48 h after the initiation of misoprostol. The main outcomes were mean abortion time, success rate, and adverse effects. Results: The mean abortion time was not significantly different between the groups (24.98 ± 16.42 h vs 25.89 ± 10.34 h, P > 0.05). The rates of abortion within 24 h and 48 h and the adverse effects were also comparable between the groups. Chills and fever were the most common adverse effects in this study. Conclusion: Intravaginal misoprostol either moistened with NSS or acetic acid was comparable in terms of efficacy and adverse effects. © 2011 The Authors. 2018-09-04T04:26:29Z 2018-09-04T04:26:29Z 2011-07-01 Journal 14470756 13418076 2-s2.0-80052763506 10.1111/j.1447-0756.2010.01458.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052763506&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50205
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Saipin Pongsatha
Theera Tongsong
Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
description Objective: To compare the efficacy and adverse effects of 400 μg intravaginal misoprostol for second-trimester pregnancy termination in live fetuses between two groups: one in which misoprostol was moistened with normal saline solution (NSS) and the other in which misoprostol was moistened with acetic acid. Materials and Methods: A total of 179 pregnant women between 14 and 28 weeks of gestation with live fetuses indicated for pregnancy termination were recruited. They were randomly allocated to receive 400 μg intravaginal misoprostol either moistened with NSS (n = 96) or moistened with acetic acid (n = 83). The same dosage was then repeated every 3 h if adequate uterine contractions were not achieved until 48 h after the initiation of misoprostol. The main outcomes were mean abortion time, success rate, and adverse effects. Results: The mean abortion time was not significantly different between the groups (24.98 ± 16.42 h vs 25.89 ± 10.34 h, P > 0.05). The rates of abortion within 24 h and 48 h and the adverse effects were also comparable between the groups. Chills and fever were the most common adverse effects in this study. Conclusion: Intravaginal misoprostol either moistened with NSS or acetic acid was comparable in terms of efficacy and adverse effects. © 2011 The Authors.
format Journal
author Saipin Pongsatha
Theera Tongsong
author_facet Saipin Pongsatha
Theera Tongsong
author_sort Saipin Pongsatha
title Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
title_short Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
title_full Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
title_fullStr Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
title_full_unstemmed Randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. Is it different?
title_sort randomized controlled study comparing misoprostol moistened with normal saline and with acetic acid for second-trimester pregnancy termination. is it different?
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052763506&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50205
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