Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia

Aim: To assess the accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia. Methods: Women aged over 35 years old with abnormal uterine bleeding who came to Chiang Mai University Hospital between June 2008 and June 2009 were invited to participat...

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Main Authors: Krida Kunaviktikul, Prapaporn Suprasert, Surapan Khunamornpong, Jongkolnee Settakorn, Apaporn Natpratan
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50224
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spelling th-cmuir.6653943832-502242018-09-04T04:26:44Z Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia Krida Kunaviktikul Prapaporn Suprasert Surapan Khunamornpong Jongkolnee Settakorn Apaporn Natpratan Medicine Aim: To assess the accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia. Methods: Women aged over 35 years old with abnormal uterine bleeding who came to Chiang Mai University Hospital between June 2008 and June 2009 were invited to participate in this study if they were candidates for the fractional curettage procedure. All patients underwent endometrial sampling prior to endometrial curettage. The endometrial samples from both procedures were separately evaluated by different pathologists. The accuracy of theWallach Endocell device in diagnosing endometrial carcinoma and hyperplasia was calculated by comparison with the final histology. When the results from both procedures were not identical, the final diagnosis was reported according to the consensus of the pathologists. Tissue adequacy was also determined. Results: During the study period, 202 patients were recruited into this study. The sensitivity, specificity, false negative rate and false positive rate of the Wallach Endocell in diagnosing endometrial carcinoma and hyperplasia were 60.00%, 99.46%, 40.00% and 0.54%, respectively. Of 13 patients with endometrial hyperplasia, six were not detected by the Wallach Endocell device. All endometrial carcinomas were detected by the endometrial sampling procedure. Tissue adequacy from the Wallach Endocell device was 85.6%. The positive predictive value and negative predictive value were 95.00% and 92.85%, respectively. Conclusions: TheWallach Endocell is an effective device for diagnosing endometrial carcinoma; however, the results of endometrial sampling should be interpreted with caution because of a high false negative rate in detecting endometrial hyperplasia. © 2010 The Authors. 2018-09-04T04:26:44Z 2018-09-04T04:26:44Z 2011-06-01 Journal 14470756 13418076 2-s2.0-80052731753 10.1111/j.1447-0756.2010.01376.x https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052731753&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50224
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Krida Kunaviktikul
Prapaporn Suprasert
Surapan Khunamornpong
Jongkolnee Settakorn
Apaporn Natpratan
Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
description Aim: To assess the accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia. Methods: Women aged over 35 years old with abnormal uterine bleeding who came to Chiang Mai University Hospital between June 2008 and June 2009 were invited to participate in this study if they were candidates for the fractional curettage procedure. All patients underwent endometrial sampling prior to endometrial curettage. The endometrial samples from both procedures were separately evaluated by different pathologists. The accuracy of theWallach Endocell device in diagnosing endometrial carcinoma and hyperplasia was calculated by comparison with the final histology. When the results from both procedures were not identical, the final diagnosis was reported according to the consensus of the pathologists. Tissue adequacy was also determined. Results: During the study period, 202 patients were recruited into this study. The sensitivity, specificity, false negative rate and false positive rate of the Wallach Endocell in diagnosing endometrial carcinoma and hyperplasia were 60.00%, 99.46%, 40.00% and 0.54%, respectively. Of 13 patients with endometrial hyperplasia, six were not detected by the Wallach Endocell device. All endometrial carcinomas were detected by the endometrial sampling procedure. Tissue adequacy from the Wallach Endocell device was 85.6%. The positive predictive value and negative predictive value were 95.00% and 92.85%, respectively. Conclusions: TheWallach Endocell is an effective device for diagnosing endometrial carcinoma; however, the results of endometrial sampling should be interpreted with caution because of a high false negative rate in detecting endometrial hyperplasia. © 2010 The Authors.
format Journal
author Krida Kunaviktikul
Prapaporn Suprasert
Surapan Khunamornpong
Jongkolnee Settakorn
Apaporn Natpratan
author_facet Krida Kunaviktikul
Prapaporn Suprasert
Surapan Khunamornpong
Jongkolnee Settakorn
Apaporn Natpratan
author_sort Krida Kunaviktikul
title Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
title_short Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
title_full Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
title_fullStr Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
title_full_unstemmed Accuracy of the Wallach Endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
title_sort accuracy of the wallach endocell endometrial cell sampler in diagnosing endometrial carcinoma and hyperplasia
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80052731753&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50224
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