Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion

Mucinous tumors of the ovary are a continuing source of controversy in the field of gynecologic pathology. We examined a series of 171 intestinal-type mucinous tumors of low malignant potential ("borderline" or "atypical proliferative" tumors) to clarify the clinical significance...

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Main Authors: Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Prapaporn Suprasert, Sumalee Siriaunkgul
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50235
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-502352018-09-04T04:26:57Z Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion Surapan Khunamornpong Jongkolnee Settakorn Kornkanok Sukpan Prapaporn Suprasert Sumalee Siriaunkgul Medicine Mucinous tumors of the ovary are a continuing source of controversy in the field of gynecologic pathology. We examined a series of 171 intestinal-type mucinous tumors of low malignant potential ("borderline" or "atypical proliferative" tumors) to clarify the clinical significance of intraepithelial carcinoma (IECA) and microinvasion (area ≤10 mm 2). The diagnosis of IECA was based on the presence of marked nuclear atypia (grade 3). Stromal microinvasion was classified as low grade and high grade (with nuclear grade 3). IECA was observed in 67 of 171 cases (39.2%). Microinvasion was identified in 31 (18.1%) cases, low grade in 22 (12.9%) cases, and high grade in 9 (5.3%) cases. Follow-up status was known in 144 cases and tumor recurrence was observed in 6 patients (4.2%). The risk factors for recurrence included International Federation of Gynecology and Obstetrics stage ≥IC (P=0.002), microinvasion (P=0.013), age less than 45 years (P=0.032), and IECA (P=0.042). The amount of IECA ≥10% was also associated with the risk of recurrence (P=0.007). Among tumors with microinvasion, there was no significant association between the clinicopathologic variables and recurrence. When considering tumors with stage ≥IC, tumor recurrence was significantly associated with IECA ≥10% (P=0.031) and age less than 45 years (P=0.047). It is important that mucinous tumors of low malignant potential should be staged and be optimally sampled for pathologic examination to document the status of the external surface or peritoneal involvement and to identify the worst degree of epithelial proliferation. Tumor stage ≥IC, IECA ≥10%, microinvasion, and age less than 45 years were the features that were associated with tumor recurrence. The study results also support the use of nuclear grade 3 as the sole criterion of IECA. © 2011 International Society of Gynecological Pathologists. 2018-09-04T04:26:57Z 2018-09-04T04:26:57Z 2011-05-01 Journal 15387151 02771691 2-s2.0-79955075470 10.1097/PGP.0b013e3181fcf01a https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955075470&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50235
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Surapan Khunamornpong
Jongkolnee Settakorn
Kornkanok Sukpan
Prapaporn Suprasert
Sumalee Siriaunkgul
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
description Mucinous tumors of the ovary are a continuing source of controversy in the field of gynecologic pathology. We examined a series of 171 intestinal-type mucinous tumors of low malignant potential ("borderline" or "atypical proliferative" tumors) to clarify the clinical significance of intraepithelial carcinoma (IECA) and microinvasion (area ≤10 mm 2). The diagnosis of IECA was based on the presence of marked nuclear atypia (grade 3). Stromal microinvasion was classified as low grade and high grade (with nuclear grade 3). IECA was observed in 67 of 171 cases (39.2%). Microinvasion was identified in 31 (18.1%) cases, low grade in 22 (12.9%) cases, and high grade in 9 (5.3%) cases. Follow-up status was known in 144 cases and tumor recurrence was observed in 6 patients (4.2%). The risk factors for recurrence included International Federation of Gynecology and Obstetrics stage ≥IC (P=0.002), microinvasion (P=0.013), age less than 45 years (P=0.032), and IECA (P=0.042). The amount of IECA ≥10% was also associated with the risk of recurrence (P=0.007). Among tumors with microinvasion, there was no significant association between the clinicopathologic variables and recurrence. When considering tumors with stage ≥IC, tumor recurrence was significantly associated with IECA ≥10% (P=0.031) and age less than 45 years (P=0.047). It is important that mucinous tumors of low malignant potential should be staged and be optimally sampled for pathologic examination to document the status of the external surface or peritoneal involvement and to identify the worst degree of epithelial proliferation. Tumor stage ≥IC, IECA ≥10%, microinvasion, and age less than 45 years were the features that were associated with tumor recurrence. The study results also support the use of nuclear grade 3 as the sole criterion of IECA. © 2011 International Society of Gynecological Pathologists.
format Journal
author Surapan Khunamornpong
Jongkolnee Settakorn
Kornkanok Sukpan
Prapaporn Suprasert
Sumalee Siriaunkgul
author_facet Surapan Khunamornpong
Jongkolnee Settakorn
Kornkanok Sukpan
Prapaporn Suprasert
Sumalee Siriaunkgul
author_sort Surapan Khunamornpong
title Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
title_short Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
title_full Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
title_fullStr Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
title_full_unstemmed Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: A study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
title_sort mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955075470&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50235
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