T-type calcium channel as a portal of iron uptake into cardiomyocytes of beta-thalassemic mice

• Main Authors: Sirinart Kumfu, Siriporn Chattipakorn, Somdet Srichairatanakool, Jongkolnee Settakorn, Suthat Fucharoen, Nipon Chattipakorn
• Format: Journal
• Published: 2018
• Subjects: Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78651447796&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50273
• Institution: Chiang Mai University

Objectives: Iron-overload condition can be found in β-thalassemic patients with regular blood transfusion, leading to iron deposition in various organs including the heart. Elevated cardiac iron causes iron-overload cardiomyopathy, a condition that provokes mortality because of heart failure in pati...