Recent developments in the genetic factors underlying congenital diaphragmatic hernia

Recent developments in the genetic factors underlying congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, i...

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Main Authors: Paul D. Brady, Kasemsri Srisupundit, Koenraad Devriendt, Jean Pierre Fryns, Jan A. Deprest, Joris R. Vermeesch
Format: Journal
Published: 2018
Subjects:
Medicine
Online Access:https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951800368&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50275
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Institution: Chiang Mai University
id th-cmuir.6653943832-50275
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spelling th-cmuir.6653943832-502752018-09-04T04:27:35Z Recent developments in the genetic factors underlying congenital diaphragmatic hernia Paul D. Brady Kasemsri Srisupundit Koenraad Devriendt Jean Pierre Fryns Jan A. Deprest Joris R. Vermeesch Medicine Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, including potential candidate genes supported by evidence from animal models. We also discuss the possible role in the pathogenesis of CDH of defective retinoid signalling and abnormal mesenchymal cell function. Copyright © 2010 S. Karger AG, Basel. 2018-09-04T04:27:35Z 2018-09-04T04:27:35Z 2011-02-01 Journal 10153837 2-s2.0-79951800368 10.1159/000322422 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951800368&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50275
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Paul D. Brady
Kasemsri Srisupundit
Koenraad Devriendt
Jean Pierre Fryns
Jan A. Deprest
Joris R. Vermeesch
Recent developments in the genetic factors underlying congenital diaphragmatic hernia
description Congenital diaphragmatic hernia (CDH) is a birth defect affecting around 1 in 3,000 births and is associated with high mortality and morbidity. It has become increasingly apparent that genetic factors underlie many forms of CDH. We review the recent developments in the area of the genetics of CDH, including potential candidate genes supported by evidence from animal models. We also discuss the possible role in the pathogenesis of CDH of defective retinoid signalling and abnormal mesenchymal cell function. Copyright © 2010 S. Karger AG, Basel.
format Journal
author Paul D. Brady
Kasemsri Srisupundit
Koenraad Devriendt
Jean Pierre Fryns
Jan A. Deprest
Joris R. Vermeesch
author_facet Paul D. Brady
Kasemsri Srisupundit
Koenraad Devriendt
Jean Pierre Fryns
Jan A. Deprest
Joris R. Vermeesch
author_sort Paul D. Brady
title Recent developments in the genetic factors underlying congenital diaphragmatic hernia
title_short Recent developments in the genetic factors underlying congenital diaphragmatic hernia
title_full Recent developments in the genetic factors underlying congenital diaphragmatic hernia
title_fullStr Recent developments in the genetic factors underlying congenital diaphragmatic hernia
title_full_unstemmed Recent developments in the genetic factors underlying congenital diaphragmatic hernia
title_sort recent developments in the genetic factors underlying congenital diaphragmatic hernia
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79951800368&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50275
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