Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease

Purpose: To determine the accuracy of splenic artery peak systolic velocity (SPA-PSV) in predicting fetal hemoglobin (Hb) Bart's disease at mid-pregnancy among fetuses at risk. Materials and Methods: Pregnant women at risk of having a fetus with Hb Bart's disease were recruited into the st...

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Main Authors: T. Tongsong, W. Piyamongkol, F. Tongprasert, K. Srisupundit, S. Luewan
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50281
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-502812018-09-04T04:27:44Z Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease T. Tongsong W. Piyamongkol F. Tongprasert K. Srisupundit S. Luewan Medicine Purpose: To determine the accuracy of splenic artery peak systolic velocity (SPA-PSV) in predicting fetal hemoglobin (Hb) Bart's disease at mid-pregnancy among fetuses at risk. Materials and Methods: Pregnant women at risk of having a fetus with Hb Bart's disease were recruited into the study at 18 - 22 weeks of gestation and underwent SPA-PSV measurement before cordocentesis. The final diagnosis used as a gold standard was based on fetal hemoglobin typing using high performance liquid chromatography (HPLC). Results: A total of 136 fetuses from 132 singleton pregnancies and 2 twin pregnancies were recruited into the study. The mean maternal age was 28.7 5.4 years, the mean gestational age was 19.1 1.02 weeks, and the incidence of Hb Bart's disease was 23.5 % (32 fetuses). Using SPA-PSV above 1.51 Multiple of Median (MoM) as a cut-off point, the sensitivity, specificity, positive predictive value and negative predictive value of SPA-PSV to identify affected fetuses was 84.4 % (32 from 36 cases), 98.1 %, 93.1 % and 95.3 % respectively. Nearly all normal fetuses had a normal SPA-PSV. Conclusion: SPA-PSV assessment at mid-pregnancy may be used as an adjunct method to identify fetuses with Hb Bart's disease with high, but not perfect, accuracy and may reduce the risk from unnecessary cordocentesis in some fetuses. © Georg Thieme Verlag KG Stuttgart · New York. 2018-09-04T04:27:44Z 2018-09-04T04:27:44Z 2011-01-24 Journal 14388782 01724614 2-s2.0-78751481553 10.1055/s-0029-1245537 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751481553&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50281
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
T. Tongsong
W. Piyamongkol
F. Tongprasert
K. Srisupundit
S. Luewan
Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
description Purpose: To determine the accuracy of splenic artery peak systolic velocity (SPA-PSV) in predicting fetal hemoglobin (Hb) Bart's disease at mid-pregnancy among fetuses at risk. Materials and Methods: Pregnant women at risk of having a fetus with Hb Bart's disease were recruited into the study at 18 - 22 weeks of gestation and underwent SPA-PSV measurement before cordocentesis. The final diagnosis used as a gold standard was based on fetal hemoglobin typing using high performance liquid chromatography (HPLC). Results: A total of 136 fetuses from 132 singleton pregnancies and 2 twin pregnancies were recruited into the study. The mean maternal age was 28.7 5.4 years, the mean gestational age was 19.1 1.02 weeks, and the incidence of Hb Bart's disease was 23.5 % (32 fetuses). Using SPA-PSV above 1.51 Multiple of Median (MoM) as a cut-off point, the sensitivity, specificity, positive predictive value and negative predictive value of SPA-PSV to identify affected fetuses was 84.4 % (32 from 36 cases), 98.1 %, 93.1 % and 95.3 % respectively. Nearly all normal fetuses had a normal SPA-PSV. Conclusion: SPA-PSV assessment at mid-pregnancy may be used as an adjunct method to identify fetuses with Hb Bart's disease with high, but not perfect, accuracy and may reduce the risk from unnecessary cordocentesis in some fetuses. © Georg Thieme Verlag KG Stuttgart · New York.
format Journal
author T. Tongsong
W. Piyamongkol
F. Tongprasert
K. Srisupundit
S. Luewan
author_facet T. Tongsong
W. Piyamongkol
F. Tongprasert
K. Srisupundit
S. Luewan
author_sort T. Tongsong
title Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
title_short Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
title_full Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
title_fullStr Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
title_full_unstemmed Fetal splenic artery peak velocity (SPA-PSV) at mid-pregnancy as a predictor of Hb Bart's disease
title_sort fetal splenic artery peak velocity (spa-psv) at mid-pregnancy as a predictor of hb bart's disease
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78751481553&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50281
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