Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach

Background: Several randomized phase III studies in advanced stage non-small cell lung cancer (NSCLC) confirmed the superior response rate and progression-free survival of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor as first-line therapy compared with chemotherapy in pati...

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Main Authors: Manuel Salto-Tellez, Ming Sound Tsao, Jin Yuan Shih, Sumitra Thongprasert, Shun Lu, Gee Chen Chang, Joseph Siu Kie Au, Teh Ying Chou, Jong Seok Lee, Yuan Kai Shi, Ahmad Radzi, Jin Hyoung Kang, Sang We Kim, Soo Yong Tan, James Chih Hsin Yang
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50312
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-503122018-09-04T04:28:18Z Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach Manuel Salto-Tellez Ming Sound Tsao Jin Yuan Shih Sumitra Thongprasert Shun Lu Gee Chen Chang Joseph Siu Kie Au Teh Ying Chou Jong Seok Lee Yuan Kai Shi Ahmad Radzi Jin Hyoung Kang Sang We Kim Soo Yong Tan James Chih Hsin Yang Medicine Background: Several randomized phase III studies in advanced stage non-small cell lung cancer (NSCLC) confirmed the superior response rate and progression-free survival of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor as first-line therapy compared with chemotherapy in patients with activating EGFR mutations. Despite the need for EGFR mutation tests to guide first-line therapy in East Asian NSCLC, there are no current standard clinical and testing protocols. Methods: A consensus meeting was held involving expert oncologists, pulmonologists, and pathologists to discuss the current status and variations in EGFR mutation testing of NSCLC across Asia and to recommend a standard clinical and laboratory testing approach for future use. Results: Currently, EGFR mutation tests are only routinely performed in some East Asian countries and medical centers. The consensus recommendation was to perform the test in all newly diagnosed patients with advanced stage nonsquamous lung cancer and some squamous patients with clinical features associated with higher prevalence of EGFR mutations. To increase the sensitivity and specificity of the EGFR mutation tests, tissue acquisition and pretest sample evaluation are important steps in addition to standardization of the EGFR mutation test methodology. Conclusion: A standardized EGFR mutation testing protocol is an essential step toward realization of personalized medicine in East Asian NSCLC treatment. © 2011 by the International Association for the Study of Lung Cancer. 2018-09-04T04:28:18Z 2018-09-04T04:28:18Z 2011-01-01 Journal 15561380 15560864 2-s2.0-80053023140 10.1097/JTO.0b013e318227816a https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053023140&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50312
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine
spellingShingle Medicine
Manuel Salto-Tellez
Ming Sound Tsao
Jin Yuan Shih
Sumitra Thongprasert
Shun Lu
Gee Chen Chang
Joseph Siu Kie Au
Teh Ying Chou
Jong Seok Lee
Yuan Kai Shi
Ahmad Radzi
Jin Hyoung Kang
Sang We Kim
Soo Yong Tan
James Chih Hsin Yang
Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
description Background: Several randomized phase III studies in advanced stage non-small cell lung cancer (NSCLC) confirmed the superior response rate and progression-free survival of using epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor as first-line therapy compared with chemotherapy in patients with activating EGFR mutations. Despite the need for EGFR mutation tests to guide first-line therapy in East Asian NSCLC, there are no current standard clinical and testing protocols. Methods: A consensus meeting was held involving expert oncologists, pulmonologists, and pathologists to discuss the current status and variations in EGFR mutation testing of NSCLC across Asia and to recommend a standard clinical and laboratory testing approach for future use. Results: Currently, EGFR mutation tests are only routinely performed in some East Asian countries and medical centers. The consensus recommendation was to perform the test in all newly diagnosed patients with advanced stage nonsquamous lung cancer and some squamous patients with clinical features associated with higher prevalence of EGFR mutations. To increase the sensitivity and specificity of the EGFR mutation tests, tissue acquisition and pretest sample evaluation are important steps in addition to standardization of the EGFR mutation test methodology. Conclusion: A standardized EGFR mutation testing protocol is an essential step toward realization of personalized medicine in East Asian NSCLC treatment. © 2011 by the International Association for the Study of Lung Cancer.
format Journal
author Manuel Salto-Tellez
Ming Sound Tsao
Jin Yuan Shih
Sumitra Thongprasert
Shun Lu
Gee Chen Chang
Joseph Siu Kie Au
Teh Ying Chou
Jong Seok Lee
Yuan Kai Shi
Ahmad Radzi
Jin Hyoung Kang
Sang We Kim
Soo Yong Tan
James Chih Hsin Yang
author_facet Manuel Salto-Tellez
Ming Sound Tsao
Jin Yuan Shih
Sumitra Thongprasert
Shun Lu
Gee Chen Chang
Joseph Siu Kie Au
Teh Ying Chou
Jong Seok Lee
Yuan Kai Shi
Ahmad Radzi
Jin Hyoung Kang
Sang We Kim
Soo Yong Tan
James Chih Hsin Yang
author_sort Manuel Salto-Tellez
title Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
title_short Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
title_full Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
title_fullStr Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
title_full_unstemmed Clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in East Asian patients with non-small cell lung cancer: A combined clinical-molecular pathological approach
title_sort clinical and testing protocols for the analysis of epidermal growth factor receptor mutations in east asian patients with non-small cell lung cancer: a combined clinical-molecular pathological approach
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80053023140&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50312
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