Pure curcumin inhibits exogenous Wilms' tumor (WT1) (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells

• Main Authors: Suwanna Semsri, Songyot Anuchapreeda, Nujeera Intasai, Tanyarat Jomgeow, Singkome Tima, Colleen Sweeney, Pornngarm Limtrakul
• Format: Journal
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=80655146486&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50324
• Institution: Chiang Mai University

Wilms' tumor (WT1) gene overexpresses in leukemic cells which is alternatively spliced at two sites, yielding four isoforms: WT1 (+/+), (+/-), (-/+), and (-/-). Curcumin is one of major active components of the spice turmeric, widely known as anticancer. This study investigated the effects and...