Mitochondrial and endoplasmic reticulum stress pathways cooperate in zearalenone-induced apoptosis of human leukemic cells

• Main Authors: Ratana Banjerdpongchai, Prachya Kongtawelert, Orawan Khantamat, Chantragan Srisomsap, Daranee Chokchaichamnankit, Pantipa Subhasitanont, Jisnuson Svasti
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78650605592&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50517
• Institution: Chiang Mai University

Background. Zearalenone (ZEA) is a phytoestrogen from Fusarium species. The aims of the study was to identify mode of human leukemic cell death induced by ZEA and the mechanisms involved. Methods. Cell cytotoxicity of ZEA on human leukemic HL-60, U937 and peripheral blood mononuclear cells (PBMCs) w...