Lung cancer working group report
Asia needs a guideline for non-small-cell lung cancer because of differences in medical care, medical care insurance, ethnic variation and drug approval lag within Asian countries and compared with Western countries. Due to ethnic differences, drug dosages are often higher in the USA than in Japan....
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th-cmuir.6653943832-505472018-09-04T04:50:42Z Lung cancer working group report Nagahiro Saijo Masahiro Fukuoka Sumitra Thongprasert Yukito Ichinose Tetsuya Mitsudomi Tony Shu Kam Mok Yuichiro Ohe Keunchil Park Yi Long Wu Biochemistry, Genetics and Molecular Biology Medicine Asia needs a guideline for non-small-cell lung cancer because of differences in medical care, medical care insurance, ethnic variation and drug approval lag within Asian countries and compared with Western countries. Due to ethnic differences, drug dosages are often higher in the USA than in Japan. EGFR mutation in non-small-cell lung cancer was detected in 32% of Asians but only 6% of non-Asians, while differences in irinotecan metabolism cause higher frequencies of toxicity (leukopenia, diarrhea) in Asians. Pharmacodynamic ethnic differences in relation to paclitaxel/carboplatin resulted in longer median survival and a higher 1-year survival rate for Japanese-advanced non-small-cell lung cancer patients compared with Americans. To solve the problem of drug lag, pharmaceutical companies must perform multinational Asian clinical trials with quick accrual of patients, while regulatory authorities must establish high-quality, efficient approval processes, and achieve regulatory harmonization. The National Comprehensive Cancer Network promotes creation of national clinical practice guidelines, and Korea, China and Thailand adapted the National Comprehensive Cancer Network guidelines. Many Asian countries still lack such guidelines, and there are no pan-Asian guidelines for non-small-cell lung cancer. Japan developed its own non-small-cell lung cancer guidelines and also a gefitinib guidance. The study group members concluded that immediate establishment of an Asian non-small-cell lung cancer guideline will be difficult because of the differences among the countries. Asian collaborative trials on treatment of non-small-cell lung cancer need to be started at an early date to generate Asian data. © The Author (2010). Published by Oxford University Press. All rights reserved. 2018-09-04T04:42:13Z 2018-09-04T04:42:13Z 2010-09-01 Journal 14653621 03682811 2-s2.0-77957280882 10.1093/jjco/hyq121 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957280882&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50547 |
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Biochemistry, Genetics and Molecular Biology Medicine Nagahiro Saijo Masahiro Fukuoka Sumitra Thongprasert Yukito Ichinose Tetsuya Mitsudomi Tony Shu Kam Mok Yuichiro Ohe Keunchil Park Yi Long Wu Lung cancer working group report |
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Asia needs a guideline for non-small-cell lung cancer because of differences in medical care, medical care insurance, ethnic variation and drug approval lag within Asian countries and compared with Western countries. Due to ethnic differences, drug dosages are often higher in the USA than in Japan. EGFR mutation in non-small-cell lung cancer was detected in 32% of Asians but only 6% of non-Asians, while differences in irinotecan metabolism cause higher frequencies of toxicity (leukopenia, diarrhea) in Asians. Pharmacodynamic ethnic differences in relation to paclitaxel/carboplatin resulted in longer median survival and a higher 1-year survival rate for Japanese-advanced non-small-cell lung cancer patients compared with Americans. To solve the problem of drug lag, pharmaceutical companies must perform multinational Asian clinical trials with quick accrual of patients, while regulatory authorities must establish high-quality, efficient approval processes, and achieve regulatory harmonization. The National Comprehensive Cancer Network promotes creation of national clinical practice guidelines, and Korea, China and Thailand adapted the National Comprehensive Cancer Network guidelines. Many Asian countries still lack such guidelines, and there are no pan-Asian guidelines for non-small-cell lung cancer. Japan developed its own non-small-cell lung cancer guidelines and also a gefitinib guidance. The study group members concluded that immediate establishment of an Asian non-small-cell lung cancer guideline will be difficult because of the differences among the countries. Asian collaborative trials on treatment of non-small-cell lung cancer need to be started at an early date to generate Asian data. © The Author (2010). Published by Oxford University Press. All rights reserved. |
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Journal |
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Nagahiro Saijo Masahiro Fukuoka Sumitra Thongprasert Yukito Ichinose Tetsuya Mitsudomi Tony Shu Kam Mok Yuichiro Ohe Keunchil Park Yi Long Wu |
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Nagahiro Saijo Masahiro Fukuoka Sumitra Thongprasert Yukito Ichinose Tetsuya Mitsudomi Tony Shu Kam Mok Yuichiro Ohe Keunchil Park Yi Long Wu |
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Nagahiro Saijo |
title |
Lung cancer working group report |
title_short |
Lung cancer working group report |
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Lung cancer working group report |
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Lung cancer working group report |
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Lung cancer working group report |
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lung cancer working group report |
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2018 |
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https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957280882&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50547 |
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