Versican facilitates chondrocyte differentiation and regulates joint morphogenesis

• Main Authors: Kanyamas Choocheep, Sonoko Hatano, Hidekazu Takagi, Hiroki Watanabe, Koji Kimata, Prachya Kongtawelert, Hideto Watanabe
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954225772&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50556
• Institution: Chiang Mai University

Versican/PG-M is a large chondroitin sulfate proteoglycan in the extracellular matrix, which is transiently expressed in mesenchymal condensation areas during tissue morphogenesis. Here, we generated versican conditional knock-out mice Prx1-Cre/Vcanflox/flox, in which Vcan is pruned out by site-spec...