Relationship among human papillomavirus infection, p16INK4a, p53 and NF-κB activation in penile cancer from northern Thailand

• Main Authors: Masachika Senba, Naoki Mori, Shuichi Fujita, Prapan Jutavijittum, Amnat Yousukh, Kan Toriyama, Akihiro Wada
• Format: Journal
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954893556&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50559
• Institution: Chiang Mai University

Human papillomavirus (HPV) E6 and E7 onco-proteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16INK4a, p53 and nuclear factor κB (NF-κB). I...