Semisynthesis and acetylcholinesterase inhibitory activity of stemofoline alkaloids and analogues

• المؤلفون الرئيسيون: Kwankamol Sastraruji, Thanapat Sastraruji, Stephen G. Pyne, Alison T. Ung, Araya Jatisatienr, Wilford Lie
• التنسيق: دورية
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952982010&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/50569
• المؤسسة: Chiang Mai University

Semisynthesis of the known Stemona alkaloids oxystemofoline (7) and methoxystemofoline (8) has been achieved starting from (11Z)-1′,2′- didehydrostemofoline (6), which confirmed their structures and absolute configurations. The synthesis of (1′R)-hydroxystemofoline (9) helped establish this compound...