Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi

Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5...

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Main Authors: Vichai Reutrakul, Natthinee Anantachoke, Manat Pohmakotr, Thaworn Jaipetch, Chalobon Yoosook, Jittra Kasisit, Chanita Napaswa, Ampai Panthong, Thawatchai Santisuk, Samran Prabpai, Palangpon Kongsaeree, Patoomratana Tuchinda
Format: Journal
Published: 2018
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http://cmuir.cmu.ac.th/jspui/handle/6653943832/50585
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-505852018-09-04T04:52:45Z Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi Vichai Reutrakul Natthinee Anantachoke Manat Pohmakotr Thaworn Jaipetch Chalobon Yoosook Jittra Kasisit Chanita Napaswa Ampai Panthong Thawatchai Santisuk Samran Prabpai Palangpon Kongsaeree Patoomratana Tuchinda Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York. 2018-09-04T04:42:38Z 2018-09-04T04:42:38Z 2010-03-12 Journal 14390221 00320943 2-s2.0-77749316840 10.1055/s-0029-1186193 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77749316840&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/50585
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Vichai Reutrakul
Natthinee Anantachoke
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswa
Ampai Panthong
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
description Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York.
format Journal
author Vichai Reutrakul
Natthinee Anantachoke
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswa
Ampai Panthong
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
author_facet Vichai Reutrakul
Natthinee Anantachoke
Manat Pohmakotr
Thaworn Jaipetch
Chalobon Yoosook
Jittra Kasisit
Chanita Napaswa
Ampai Panthong
Thawatchai Santisuk
Samran Prabpai
Palangpon Kongsaeree
Patoomratana Tuchinda
author_sort Vichai Reutrakul
title Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_short Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_full Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_fullStr Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_full_unstemmed Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_sort anti-hiv1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
publishDate 2018
url https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77749316840&origin=inward
http://cmuir.cmu.ac.th/jspui/handle/6653943832/50585
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